Evidence map›Paper›PMID 38751615›Full record

ArticleACS pharmacology & translational science2024

Cellular and Mitochondrial Toxicity of Tolcapone, Entacapone, and New Nitrocatechol Derivatives.

Miguel Pinto, Tiago Barros Silva, Vilma A Sardão, Rui Simões, Bárbara Albuquerque, Paulo J Oliveira, Maria João Valente, Fernando Remião, Patrício Soares-da-Silva, Carlos Fernandes and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miguel PintoCIQUP-IMS - Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, Porto 4169-007, Portugal.
Tiago Barros SilvaCIQUP-IMS - Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, Porto 4169-007, Portugal.
Vilma A SardãoCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal.
Rui SimõesCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal.
Bárbara AlbuquerqueCIQUP-IMS - Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, Porto 4169-007, Portugal.
Paulo J OliveiraCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal.
Maria João ValenteAssociate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, Porto 4050-313, Portugal.
Fernando RemiãoAssociate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, Porto 4050-313, Portugal.ORCID https://orcid.org/0000-0003-1382-5119
Patrício Soares-da-SilvaMedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto 4200-319, Portugal.ORCID https://orcid.org/0000-0002-2446-5078
Carlos FernandesCIQUP-IMS - Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, Porto 4169-007, Portugal.ORCID https://orcid.org/0000-0002-0102-0703
Fernanda BorgesCIQUP-IMS - Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, Porto 4169-007, Portugal.ORCID https://orcid.org/0000-0003-1050-2402

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitrocatechols are the standard pharmacophore to develop potent tight-binding inhibitors of catechol

Identifiers

PMID38751615
PMCPMC11091965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.