Evidence map›Paper›PMID 38751495›Full record

ArticleOcular oncology and pathology2024

Retinoblastoma with MYCN Amplification Diagnosed from Cell-Free DNA in the Aqueous Humor.

Sarah Joseph, Sarah Pike, Chen-Ching Peng, Brianne Brown, Liya Xu, Jesse L Berry, Patricia Chévez-Barrios, G Baker Hubbard, Hans E Grossniklaus

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular oncology and pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Retinoblastoma: Aqueous humor liquid biopsy.Taiwan journal of ophthalmology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah JosephDepartment of Ophthalmology, Emory University School of Medicine, Los Angeles, CA, USA.
Sarah PikeChildren's Hospital Los Angeles and the USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Chen-Ching PengChildren's Hospital Los Angeles and the USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brianne BrownChildren's Hospital Los Angeles and the USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Liya XuChildren's Hospital Los Angeles and the USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jesse L BerryChildren's Hospital Los Angeles and the USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Patricia Chévez-BarriosDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
G Baker HubbardDepartment of Ophthalmology, Emory University School of Medicine, Los Angeles, CA, USA.
Hans E GrossniklausDepartment of Ophthalmology, Emory University School of Medicine, Los Angeles, CA, USA.

Funding

P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI NICKERSON, JOHN M · 1986 to 2025
$15.3M
Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
VIsion Science Training in AtlantaT32EY007092 · NEI · EMORY UNIVERSITY · PI Machelle T. Pardue · 1985 to 2026
$4.6M
NEI NIH HHS P30 EY006360NEI NIH HHS P30 EY029220NEI NIH HHS T32 EY007092
6 · The paper itself

Abstract

Introduction: The objective of this study was to report the clinicopathologic features of three cases of Methods: Whole-genome sequencing was performed using isolated cell-free DNA (cfDNA) from aqueous humor of 3 retinoblastoma patients. We analyzed genomic copy number and mutational alterations, histologic and pathologic features, and clinical data. Results: The most common genetic alteration identified in these three retinoblastoma cases was a focal Conclusions: Our report shows 3 cases of unilateral retinoblastomas diagnosed in patients ranging from 4 months to 18 months old. Genomic analysis from AH cfDNA revealed Importance:

Indexed as

Aqueous humorLeukocoriaOncogeneRetinoblastomaVitreous

Identifiers

PMID38751495
PMCPMC11095586

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.