Evidence map›Paper›PMID 38751442›Full record

ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2024

IMpower210: A phase III study of second-line atezolizumab

Yi-Long Wu, Shun Lu, Gongyan Chen, Jianxing He, Jifeng Feng, Yiping Zhang, Liyan Jiang, Hongming Pan, Jianhua Chang, Jian Fang and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02813785 (A Phase III, Open-Label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of Atezolizumab), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02813785 phase3completednot on this map

A Phase III, Open-Label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of Atezolizumab (Anti-PD-L1 Antibody) Compared With Docetaxel in Patients With Non-Small Cell Lung Cancer After Failure With Platinum-Containing Chemotherapy

TypeinterventionalSponsorHoffmann-La RocheRan2016 to 2022Enrolled565ConditionsCarcinoma, Non-Small-Cell LungArmsAtezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody, Docetaxel
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yi-Long WuGuangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China.
Shun LuShanghai Lung Cancer Center, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Gongyan ChenDepartment of Respiration, Harbin Cancer Hospital, Harbin Medical University, Harbin 150081, China.
Jianxing HeDepartment of Thoracic Oncology and Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Jifeng FengDepartment of Medical Oncology, Jiangsu Cancer Hospital, Nanjing 210009, China.
Yiping ZhangDepartment of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 330022, China.
Liyan JiangDepartment of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Hongming PanDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Jianhua ChangDepartment of Medical Oncology, Shenzhen Hospital, Cancer Hospital of Chinese Academy of Medical Sciences, Shenzhen 518116, China.
Jian FangDepartment of Thoracic Oncology, Beijing Cancer Hospital, Beijing 100142, China.
Amy CaiProduct Development, Shanghai Roche Pharmaceutical Ltd, Shanghai 201203, China.
Lilian BuProduct Development, Shanghai Roche Pharmaceutical Ltd, Shanghai 201203, China.
Jane ShiProduct Development, Shanghai Roche Pharmaceutical Ltd, Shanghai 201203, China.
Jinjing XiaProduct Development, Shanghai Roche Pharmaceutical Ltd, Shanghai 201203, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: IMpower210 (NCT02813785) explored the efficacy and safety of single-agent atezolizumab Methods: Key eligibility criteria for this phase III, open-label, randomized study included age ≥18 years; histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system (7th edition); Eastern Cooperative Oncology Group performance status of 0 or 1; and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab (1,200 mg) or docetaxel (75 mg/m Results: Median OS in the ITT Conclusions: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT

Indexed as

AtezolizumabEast Asiamonoclonal antibodynon-small cell lung cancerprogrammed death-ligand 1 inhibitors

Identifiers

PMID38751442
PMCPMC11090799

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.