Evidence map›Paper›PMID 38751411›Full record

ArticleJAMIA open2024

Integrating clinical research into electronic health record workflows to support a learning health system.

Nicole H Goldhaber, Marni B Jacobs, Louise C Laurent, Rob Knight, Wenhong Zhu, Dean Pham, Allen Tran, Sandip P Patel, Michael Hogarth, Christopher A Longhurst

Abstract readCase Reports
In one paragraph

Article in JAMIA open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. A standards-based approach to digital health research: implementing the people heart study.Journal of the American Medical Informatics Association : JAMIA · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicole H GoldhaberDepartment of Surgery, University of California San Diego Health, La Jolla, CA 92037, United States.ORCID https://orcid.org/0000-0002-3847-3634
Marni B JacobsDepartment of Obstetrics, Gynecology and Reproductive Services, University of California San Diego Health, La Jolla, CA 92037, United States.
Louise C LaurentDepartment of Obstetrics, Gynecology and Reproductive Services, University of California San Diego Health, La Jolla, CA 92037, United States.
Rob KnightDepartment of Pediatrics, University of California San Diego Health, La Jolla, CA 92037, United States.
Wenhong ZhuInformation Services, University of California San Diego Health, La Jolla, CA 92037, United States.
Dean PhamInformation Services, University of California San Diego Health, La Jolla, CA 92037, United States.
Allen TranInformation Services, University of California San Diego Health, La Jolla, CA 92037, United States.
Sandip P PatelDivision of Oncology, Department of Medicine, University of San Diego Health, La Jolla, CA 92037, United States.
Michael HogarthDivision of Biomedical Informatics, Department of Medicine, University of San Diego Health, La Jolla, CA 92037, United States.
Christopher A LonghurstDepartment of Pediatrics, University of California San Diego Health, La Jolla, CA 92037, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Integrating clinical research into routine clinical care workflows within electronic health record systems (EHRs) can be challenging, expensive, and labor-intensive. This case study presents a large-scale clinical research project conducted entirely within a commercial EHR during the COVID-19 pandemic. Case Report: The UCSD and UCSDH COVID-19 NeutraliZing Antibody Project (ZAP) aimed to evaluate antibody levels to SARS-CoV-2 virus in a large population at an academic medical center and examine the association between antibody levels and subsequent infection diagnosis. Results: The project rapidly and successfully enrolled and consented over 2000 participants, integrating the research trial with standing COVID-19 testing operations, staff, lab, and mobile applications. EHR-integration increased enrollment, ease of scheduling, survey distribution, and return of research results at a low cost by utilizing existing resources. Conclusion: The case study highlights the potential benefits of EHR-integrated clinical research, expanding their reach across multiple health systems and facilitating rapid learning during a global health crisis.

Indexed as

clinical informaticsclinical researchCOVID-19 antibodiesEHR-integrationinteroperability

Identifiers

PMID38751411
PMCPMC11095974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.