Evidence map›Paper›PMID 38751364›Full record

SynthesisJournal of diabetes2024

Diabetes and gastric cancer incidence and mortality in the Asia Cohort Consortium: A pooled analysis of more than a half million participants.

Katherine De la Torre, Minkyo Song, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Sukhong Min, Dan Huang, Yu Chen, Prakash C Gupta and 28 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Katherine De la TorreDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Minkyo SongInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Sarah Krull AbeDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Md Shafiur RahmanDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Md Rashedul IslamDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Eiko SaitoInstitute for Global Health Policy Research, National Center for Global Health and Medicine, Tokyo, Japan.
Sukhong MinDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Dan HuangDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Yu ChenDepartment of Population Health and Environmental Medicine, NYU Grossman School of Medicine, New York, New York, USA.
Prakash C GuptaHealis - Sekhsaria Institute for Public Health, Navi Mumbai, India.
Norie SawadaDivision of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Akiko TamakoshiDepartment of Public Health, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ritsu SakataRadiation Effects Research Foundation, Hiroshima, Japan.
Jeongseon KimGraduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
Chisato NagataDepartment of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Hidemi ItoDepartment of Preventive Medicine, Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan.
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Myung-Hee ShinDepartment of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
Mangesh S PednekarHealis - Sekhsaria Institute for Public Health, Navi Mumbai, India.
Shoichiro TsuganeDivision of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Takashi KimuraDepartment of Public Health, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Hui CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Keiko WadaDepartment of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Isao OzeDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Aesun ShinDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Yoon-Ok AhnDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Habibul AhsanDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Paolo BoffettaStony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA.
Kee Seng ChiaSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
You-Lin QiaoSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Nathaniel RothmanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Manami InoueDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Daehee KangDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4031-5878

Funding

Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
Shanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9M
Cancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7M
International Agency for Research on Cancer, Lyon, FranceMinistry of Education, Culture, Sports, Science and Technology, JapanMinistry of Health, Labour and Welfare of Japan 23-A-31National Cancer Center Japan Research and Development Fund 30-A-15,23-A-31(toku),26-A-2,29-A-4National Cancer Center Korea Research Grant 2210990National Cancer Center Korea Research Grant 24H1080National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea 0520160-1National Research Foundation of Korea NRF-2016R1A2B4014552NCI NIH HHS R37 CA070867NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910The Japanese Ministry of the EnvironmentUS Department of Energy
6 · The paper itself

Abstract

backgroundEvidence suggests a possible link between diabetes and gastric cancer risk, but the findings remain inconclusive, with limited studies in the Asian population. We aimed to assess the impact of diabetes and diabetes duration on the development of gastric cancer overall, by anatomical and histological subtypes.

methodsA pooled analysis was conducted using 12 prospective studies included in the Asia Cohort Consortium. Among 558 981 participants (median age 52), after a median follow-up of 14.9 years and 10.5 years, 8556 incident primary gastric cancers and 8058 gastric cancer deaths occurred, respectively. Cox proportional hazard regression models were used to estimate study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) and pooled using random-effects meta-analyses.

resultsDiabetes was associated with an increased incidence of overall gastric cancer (HR 1.15, 95% CI 1.06-1.25). The risk association did not differ significantly by sex (women vs men: HR 1.31, 95% CI 1.07-1.60 vs 1.12, 1.01-1.23), anatomical subsites (noncardia vs cardia: 1.14, 1.02-1.28 vs 1.17, 0.77-1.78) and histological subtypes (intestinal vs diffuse: 1.22, 1.02-1.46 vs 1.00, 0.62-1.61). Gastric cancer risk increased significantly during the first decade following diabetes diagnosis (HR 4.70, 95% CI 3.77-5.86), and decreased with time (nonlinear p < .01). Positive associations between diabetes and gastric cancer mortality were observed (HR 1.15, 95% CI 1.03-1.28) but attenuated after a 2-year time lag.

conclusionDiabetes was associated with an increased gastric cancer incidence regardless of sex, anatomical subsite, or subtypes of gastric cancer. The risk of gastric cancer was particularly high during the first decade following diabetes diagnosis.

Indexed as

Diabetes MellitusStomach NeoplasmsAdultAgedAsiaCohort StudiesFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsAsiadiabetesgastric cancerincidencemortalityprospective studies

Identifiers

PMID38751364
PMCPMC11096812

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.