Evidence map›Paper›PMID 38751165›Full record

ArticleInfluenza and other respiratory viruses2024

Geographic Progression of Infant Respiratory Syncytial Virus Associated Bronchiolitis Across the United States Before and Since the Onset of COVID-19: Results From Four Health Systems, 2015-2023.

Adam Z Blatt, Mina Suh, Emmanuel B Walter, Charles T Wood, Claudia Espinosa, Maria E Enriquez-Bruce, Joseph Domachowske, Danielle Daniels, Sonia Budhecha, Amanda Elliott and 6 more

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Adam Z BlattPediatric Infectious Diseases, Duke University Health System, Durham, North Carolina, USA.ORCID 0000-0002-6363-3089
Mina SuhEpidStrategies, A Division of ToxStrategies, Rockville, Maryland, USA.
Emmanuel B WalterPediatric Infectious Diseases, Duke University Health System, Durham, North Carolina, USA.
Charles T WoodGeneral Pediatrics and Adolescent Health, Duke University Health System, Durham, North Carolina, USA.
Claudia EspinosaPediatric Infectious Diseases, University of South Florida Health, Tampa, Florida, USA.
Maria E Enriquez-BrucePediatric Infectious Diseases, University of South Florida Health, Tampa, Florida, USA.
Joseph DomachowskePediatric Infectious Diseases, State University of New York Upstate Medical University, Syracuse, New York, USA.
Danielle DanielsPediatric Infectious Diseases, State University of New York Upstate Medical University, Syracuse, New York, USA.
Sonia BudhechaPediatric Pulmonology, Renown Health, Reno, Nevada, USA.
Amanda ElliottUniversity of Nevada, Reno School of Medicine, Nevada, Reno, USA.
Zachary WolfClinetic, Durham, North Carolina, USA.
Emory B WaddellClinetic, Durham, North Carolina, USA.
Naimisha MovvaEpidStrategies, A Division of ToxStrategies, Rockville, Maryland, USA.
Heidi ReichertEpidStrategies, A Division of ToxStrategies, Rockville, Maryland, USA.
Jon P FryzekEpidStrategies, A Division of ToxStrategies, Rockville, Maryland, USA.
Christopher B NelsonSanofi, Swiftwater, Pennsylvania, USA.

Funding

AstraZenecaSanofi
6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is a substantial cause of infant morbidity and mortality due to seasonal peaks of bronchiolitis across the United States. Clinical and viral surveillance plays a pivotal role in helping hospital systems prepare for expected surges in RSV bronchiolitis. Existing surveillance efforts have shown a geographic pattern of RSV positivity across the United States, with cases typically starting in the southeast and spreading north and west. Public health measures implemented due to the COVID-19 pandemic disrupted viral transmission across the nation and altered the expected seasonality of RSV. The impact of these changes on the geographic progression of infant RSV bronchiolitis across the United States has not been described.

methodsHere, we used clinical and viral surveillance data from four health care systems located in different regions of the United States to describe the geographic progression of infant RSV bronchiolitis across the country from 2015 to 2023.

resultsPrior to widespread circulation of SARS-CoV-2, infant RSV bronchiolitis followed an established geographic pattern associated with seasonal epidemics originating in Florida and spreading north (North Carolina and New York) and later westward (Nevada). Although public health and social measures implemented during the COVID-19 pandemic disrupted the seasonality of RSV disease, infant RSV bronchiolitis epidemics progressed across the nation in a pattern identical to the prepandemic era.

conclusionsOur findings highlight the importance of ongoing clinical and viral surveillance to optimally track the onset of RSV epidemics and allow health care systems to prepare for expected RSV bronchiolitis surges.

Indexed as

BronchiolitisCOVID-19Respiratory Syncytial Virus InfectionsFemaleHumansInfantInfant, NewbornMaleRespiratory Syncytial Virus, HumanSARS-CoV-2SeasonsUnited Statesepidemiologyrespiratory syncytial virusseasonalitysurveillance

Identifiers

PMID38751165
PMCPMC11096694

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.