Evidence map›Paper›PMID 38751110›Full record

ArticleInternational journal of cancer2024

Misspellings or "miscellings"-Non-verifiable and unknown cell lines in cancer research publications.

Danielle J Oste, Pranujan Pathmendra, Reese A K Richardson, Gracen Johnson, Yida Ao, Maya D Arya, Naomi R Enochs, Muhammed Hussein, Jinghan Kang, Aaron Lee and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Cell line authentication and validation is a key requirement forJournal of cell communication and signaling · 2025
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Danielle J OsteSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Pranujan PathmendraSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Reese A K RichardsonDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA.
Gracen JohnsonSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Yida AoSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Maya D AryaSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Naomi R EnochsSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Muhammed HusseinSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Jinghan KangSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Aaron LeeSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Jonathan J DanonSchool of Chemistry, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia.
Guillaume CabanacIRIT UMR 5505 CNRS, University of Toulouse, Toulouse, France.
Cyril LabbéCNRS, Grenoble INP, Laboratoire d'Informatique de Grenoble, Université Grenoble Alpes, Grenoble, France.
Amanda Capes DavisCellBank Australia, Children's Medical Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
Thomas StoegerFeinberg School of Medicine in the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, USA.
Jennifer A ByrneSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-8923-0587

Funding

Integrative Multi-Scale Systems Analysis of Gene-Expression-Driven Aging MorbidityR00AG068544 · NIA · NORTHWESTERN UNIVERSITY · PI Thomas Stoeger · 2024 to 2026
$720k
Integrative Multi-Scale Systems Analysis of Gene-Expression-Driven Aging Morbidity - SupplementK99AG068544 · NIA · NORTHWESTERN UNIVERSITY · PI STOEGER, THOMAS · 2020 to 2022
$280k
Moderna IncNational Health and Medical Research Council of Australia (NHMRC) Ideas Grant APP1184263NHMRC Investigator Grant GNT2008066NIA NIH HHS K99 AG068544NIA NIH HHS R00 AG068544NIH(USA) AG068544Northwestern UniversityUniversity of Sydney
6 · The paper itself

Abstract

Reproducible laboratory research relies on correctly identified reagents. We have previously described gene research papers with wrongly identified nucleotide sequence(s), including papers studying miR-145. Manually verifying reagent identities in 36 recent miR-145 papers found that 56% and 17% of papers described misidentified nucleotide sequences and cell lines, respectively. We also found 5 cell line identifiers in miR-145 papers with misidentified nucleotide sequences and cell lines, and 18 cell line identifiers published elsewhere, that did not represent indexed human cell lines. These 23 identifiers were described as non-verifiable (NV), as their identities were unclear. Studying 420 papers that mentioned 8 NV identifier(s) found 235 papers (56%) that referred to 7 identifiers (BGC-803, BSG-803, BSG-823, GSE-1, HGC-7901, HGC-803, and MGC-823) as independent cell lines. We could not find any publications describing how these cell lines were established. Six cell lines were sourced from cell line repositories with externally accessible online catalogs, but these cell lines were not indexed as claimed. Some papers also stated that short tandem repeat (STR) profiles had been generated for three cell lines, yet no STR profiles could be identified. In summary, as NV cell lines represent new challenges to research integrity and reproducibility, further investigations are required to clarify their status and identities.

Indexed as

NeoplasmsBiomedical ResearchCell Line, TumorHumansMicroRNAsPublicationsMicroRNAscancercell linesnon‐verifiablereagentswrongly identified

Identifiers

PMID38751110
PMCPMC11296894

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.