Evidence map›Paper›PMID 38750594›Full record

ArticleVeterinary research2024

Classical BSE dismissed as the cause of CWD in Norwegian red deer despite strain similarities between both prion agents.

Alba Marín-Moreno, Sylvie L Benestad, Tomas Barrio, Laura Pirisinu, Juan Carlos Espinosa, Linh Tran, Alvina Huor, Michele Angelo Di Bari, Hasier Eraña, Ben C Maddison and 12 more

Abstract read
In one paragraph

Article in Veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Alba Marín-Moreno *Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Sylvie L Benestad *Norwegian Veterinary Institute, Ås, Norway.
Tomas BarrioUMR École Nationale Vétérinaire de Toulouse (ENVT), 1225 Interactions Hôtes-Agents Pathogènes, Institut National Pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), Toulouse, France.
Laura PirisinuDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Juan Carlos EspinosaCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Linh TranNorwegian Veterinary Institute, Ås, Norway.
Alvina HuorUMR École Nationale Vétérinaire de Toulouse (ENVT), 1225 Interactions Hôtes-Agents Pathogènes, Institut National Pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), Toulouse, France.
Michele Angelo Di BariDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Hasier ErañaCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Basque Foundation for Science, Bizkaia Technology Park & IKERBASQUE, Bizkaia, Spain.
Ben C MaddisonRSK- ADAS Ltd, Technology Drive, Beeston, Nottingham, UK.
Claudia D'AgostinoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Natalia Fernández-BorgesCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Sara CanoyraCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Nuria Jerez-GarridoCentro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Joaquín CastillaCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Basque Foundation for Science, Bizkaia Technology Park & IKERBASQUE, Bizkaia, Spain.
John SpiropoulosAnimal and Plant Health Agency (APHA), Weybridge, UK.
Keith BishopRSK- ADAS Ltd, Technology Drive, Beeston, Nottingham, UK.
Kevin C GoughUniversity of Nottingham, Nottingham, UK.
Romolo NonnoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Jorn VågeNorwegian Veterinary Institute, Ås, Norway.
Olivier Andréoletti *UMR École Nationale Vétérinaire de Toulouse (ENVT), 1225 Interactions Hôtes-Agents Pathogènes, Institut National Pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), Toulouse, France.
Juan María Torres *Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain. jmtorres@inia.csic.es.ORCID http://orcid.org/0000-0003-0443-9232

Funding

EU-CWD ANR-20-CE35-0015International coordination of research on infectious animal diseases (ICRAD) 322907Istituto Superiore di Sanita ISS20-97e1d82bda5aMinisterio de Ciencia e Innovación PCI2020-120680-2Ministerio de Ciencia e Innovación PID2019-105837RB-I00Ministerio de Ciencia e Innovación PID2021-122201OB-C21Norwegian Veterinary Institute 12081
6 · The paper itself

Abstract

The first case of CWD in a Norwegian red deer was detected by a routine ELISA test and confirmed by western blotting and immunohistochemistry in the brain stem of the animal. Two different western blotting tests were conducted independently in two different laboratories, showing that the red deer glycoprofile was different from the Norwegian CWD reindeer and CWD moose and from North American CWD. The isolate showed nevertheless features similar to the classical BSE (BSE-C) strain. Furthermore, BSE-C could not be excluded based on the PrP

Indexed as

DeerEncephalopathy, Bovine SpongiformWasting Disease, ChronicAnimalsBlotting, WesternCattleEnzyme-Linked Immunosorbent AssayImmunohistochemistryNorwayPrionsPrPSc ProteinsPrionsPrPSc Proteinsbovine spongiform encephalopathyBSEchronic wasting diseaseCWDphenotypical convergencePrionprion strainspecies barrier

Identifiers

PMID38750594
PMCPMC11097568

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.