Evidence map›Paper›PMID 38750586›Full record

ArticleTrials2024

Comparing effectiveness of physiotherapy versus drug management on fatigue, physical functioning, and episodic disability for myalgic encephalomyelitis in post-COVID-19 condition: a study protocol of randomized control trial.

Altaf Hossain Sarker, K M Amran Hossain, Md Feroz Kabir, Sharmila Jahan, Md Zahid Hossain, Tofajjal Hossain, Iqbal Kabir Jahid

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Altaf Hossain SarkerDepartment of Microbiology, Jashore University of Science and Technology (JUST), Jashore, 7408, Bangladesh.
K M Amran HossainDepartment of Physiotherapy and Rehabilitation, Jashore University of Science and Technology (JUST), Jashore, 7408, Bangladesh.
Md Feroz KabirDepartment of Physiotherapy and Rehabilitation, Jashore University of Science and Technology (JUST), Jashore, 7408, Bangladesh.
Sharmila JahanDepartment of Physiotherapy and Rehabilitation, Jashore University of Science and Technology (JUST), Jashore, 7408, Bangladesh.
Md Zahid HossainDepartment of Physiotherapy and Rehabilitation, Jashore University of Science and Technology (JUST), Jashore, 7408, Bangladesh.
Tofajjal HossainDepartment of Physiotherapy and Rehabilitation, Jashore University of Science and Technology (JUST), Jashore, 7408, Bangladesh.
Iqbal Kabir JahidDepartment of Microbiology, Jashore University of Science and Technology (JUST), Jashore, 7408, Bangladesh. ikjahid_mb@just.edu.bd.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysiotherapy interventions effectively improved fatigue and physical functioning in non-COVID patients with myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). There is a research gap on the effectiveness of physiotherapy interventions versus drug management on ME/CFS in post-COVID-19 conditions (PCC).

methodsWe planned a three-arm prospective randomized control trial on 135 PCC cases with ME/CFS who are diagnosed between 20 November 2023 and 20 May 2024 from a population-based cohort. The study aims to determine the effectiveness of physiotherapy interventions as adapted physical activity and therapeutic exercise (APTE) provided in institution-based care versus telemedicine compared with drug management (DM). Participants will be assigned to three groups with the concealed location process and block randomization with an enrollment ratio of 1:1:1. The post-treatment evaluation will be employed after 2 months of interventions, and follow-up will be taken after 6 months post-intervention. The Chalder fatigue scale will measure the primary outcome of fatigue. SF-36 and the disability-adjusted life years (DALYs) will measure the secondary outcome of physical functioning and episodic disability. DISCUSSION: This study will address the research gap to determine the appropriate approach of physiotherapy or drug management for ME/CFS in PCC cases. The future direction of the study will contribute to developing evidence-based practice in post-COVID-19 condition rehabilitation.

trial registrationThe trial is registered prospectively from a primary Clinical Trial Registry side of WHO CTRI/2024/01/061987. Registered on 29 January 2024.

Indexed as

COVID-19Fatigue Syndrome, ChronicPhysical Therapy ModalitiesRandomized Controlled Trials as TopicSARS-CoV-2AdultDisability EvaluationExercise TherapyFatigueHumansProspective StudiesTelemedicineTreatment OutcomeDrugMyalgic encephalomyelitisPhysiotherapyPost-COVID-19 conditionRandomized controlled trial

Identifiers

PMID38750586
PMCPMC11094988

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.