Evidence map›Paper›PMID 38750398›Full record

ArticleEJNMMI research2024

In vivo assessment of safety, biodistribution, and radiation dosimetry of the [

Barbara Katharina Geist, Juan Carlos Ramirez, Patrick Binder, Holger Einspieler, Harald Ibeschitz, Werner Langsteger, Lukas Nics, Ivo Rausch, Markus Diemling, Antti Sohlberg and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03557138 (Study to Develop a Kinetic Model for FDG and Me4FDG in Kidneys of Type 2 Diabetic Patients With SGLT2 Inhibitor Therapies), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03557138 naunknown statusnot on this map

Study to Develop a Kinetic Model for FDG and Me4FDG in Kidneys of Type 2 Diabetic Patients With SGLT2 Inhibitor Therapies

TypeinterventionalSponsorMedical University of ViennaRan2017 to 2020Enrolled20ConditionsType2 Diabetes MellitusArmsalpha-Methyl-4-deoxy-4-[(18)F]fluoro-D-glucopyranoside
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Barbara Katharina GeistDivision of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Juan Carlos RamirezDivision of Nuclear Medicine, Unisanitas, Bogota, Cundinamarca, Colombia.
Patrick BinderDivision of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Holger EinspielerDivision of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Harald IbeschitzDivision of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Werner LangstegerDivision of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Lukas NicsDivision of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Ivo RauschCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Markus DiemlingHermes Medical Solutions, Vienna, Austria.
Antti SohlbergHermes Medical Solutions, Vienna, Austria.
Marcus HackerDivision of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. marcus.hacker@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-4222-4083
Sazan RasulDivision of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApproaches targeting the sodium-glucose cotransporter (SGLT) could represent a promising future therapeutic strategy for numerous oncological and metabolic diseases. In this study, we evaluated the safety, biodistribution and radiation dosimetry of the glucose analogue positron emission tomography (PET) agent [

resultsAll studied volunteers could well tolerate the [

conclusionFeaturing an effective dose of only 0.013 ± 0.003 mSv/MBq and no occurrence of side effects, the glucose analogue [ TRIAL REGISTRATION NUMBER: NCT03557138, Registered 22 February 2017, https://ichgcp.net/clinical-trials-registry/NCT03557138 .

Indexed as

[18F]DosimetryMe4FDGToxicityTracer biodistribution

Identifiers

PMID38750398
PMCPMC11096136

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.