Evidence map›Paper›PMID 38750394›Full record

ArticleNeurocritical care2024

Hyperbaric Oxygen Therapy Reduces the Traumatic Brain Injury-Mediated Neuroinflammation Through Enrichment of Prevotella Copri in the Gut of Male Rats.

Tee-Tau Eric Nyam, Hsiao-Yue Wee, Min-Hsi Chiu, Kuan-Chi Tu, Che-Chuan Wang, Yao-Tsung Yeh, Ching-Lung Kuo

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Article in Neurocritical care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tee-Tau Eric Nyam *Department of Neurosurgery, Chi Mei Medical Center, 901 Chung Hwa Road, Yung Kang Dist., Tainan, 71004, Taiwan.
Hsiao-Yue Wee *Department of Neurosurgery, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
Min-Hsi ChiuAging and Disease Prevention Research Center, Fooyin University, Kaohsiung, Taiwan.
Kuan-Chi TuDepartment of Neurosurgery, Chi Mei Medical Center, 901 Chung Hwa Road, Yung Kang Dist., Tainan, 71004, Taiwan.
Che-Chuan WangDepartment of Neurosurgery, Chi Mei Medical Center, 901 Chung Hwa Road, Yung Kang Dist., Tainan, 71004, Taiwan.
Yao-Tsung YehAging and Disease Prevention Research Center, Fooyin University, Kaohsiung, Taiwan. ft023@fy.edu.tw.
Ching-Lung KuoDepartment of Neurosurgery, Chi Mei Medical Center, 901 Chung Hwa Road, Yung Kang Dist., Tainan, 71004, Taiwan. cmh7520@mail.chimei.org.tw.

Funding

Ministry of Science and Technology 111-2314-B-384-011
6 · The paper itself

Abstract

backgroundGastrointestinal dysfunction frequently occurs following traumatic brain injury (TBI) and significantly increases posttraumatic complications. TBI can lead to alterations in gut microbiota. The neuroprotective effects of hyperbaric oxygen (HBO) have not been well recognized after TBI. The study''s aim was to investigate the impact of HBO on TBI-induced dysbiosis in the gut and the pathological changes in the brain following TBI.

methodsAnesthetized male Sprague-Dawley rats were randomly assigned to three groups: sham surgery plus normobaric air (21% oxygen at 1 atmospheres absolute), TBI (2.0 atm) plus normobaric air, and TBI (2.0 atm) plus HBO (100% oxygen at 2.0 atmospheres absolute) for 60 min immediately after TBI, 24 h later, and 48 h later. The brain injury volume, tumor necrosis factor-α expression in microglia and astrocytes, and neuronal apoptosis in the brain were subsequently determined. The V3-V4 regions of 16S ribosomal rRNA in the fecal samples were sequenced, and alterations in the gut microbiome were statistically analyzed. All parameters were evaluated on the 3rd day after TBI.

resultsOur results demonstrated that HBO improved TBI-induced neuroinflammation, brain injury volume, and neuronal apoptosis. HBO appeared to increase the abundance of aerobic bacteria while inhibiting anaerobic bacteria. Intriguingly, HBO reversed the TBI-mediated decrease in Prevotella copri and Deinococcus spp., both of which were negatively correlated with neuroinflammation and brain injury volume. TBI increased the abundance of these gut bacteria in relation to NOD-lik0065 receptor signaling and the proteasome pathway, which also exhibited a positive correlation trend with neuro inflammation and apoptosis. The abundance of Prevotella copri was negatively correlated with NOD-like receptor signaling and the Proteasome pathway.

conclusionsOur study demonstrated how the neuroprotective effects of HBO after acute TBI might act through reshaping the TBI-induced gut dysbiosis and reversing the TBI-mediated decrease of Prevotella copri.

Indexed as

Brain Injuries, TraumaticGastrointestinal MicrobiomeHyperbaric OxygenationNeuroinflammatory DiseasesPrevotellaRats, Sprague-DawleyAnimalsDysbiosisMaleRatsBrain–-gut axisGut microbiotaNeuro-inflammationTraumatic brain injuryTumor necrosis factor alpha

Identifiers

PMID38750394
PMCPMC11599330

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.