Evidence map›Paper›PMID 38750383›Full record

ReviewCell biochemistry and biophysics2024

Molecular Mechanisms of Tumorgenesis and Metastasis of Long Non-coding RNA (lncRNA) NEAT1 in Human Solid Tumors; An Update.

Mohammad Y Alshahrani, Raed Obaid Saleh, Ahmed Hjazi, Pooja Bansal, Harpreet Kaur, Mahamedha Deorari, Farag M A Altalbawy, Anaheed Hussein Kareem, Hamza Fadhel Hamzah, Bahira Abdulrazzaq Mohammed

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In one paragraph

Review in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammad Y AlshahraniDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia.
Raed Obaid SalehDepartment of Pathological Analysis, College of Applied Science, University of Fallujah, Al-Maarif University College, Al-Anbar, Iraq. raed.obaid@uofallujah.edu.iq.
Ahmed HjaziDepartment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
Pooja BansalDepartment of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bengaluru, Karnataka, 560069, India.
Harpreet KaurSchool of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India.
Mahamedha DeorariUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
Farag M A AltalbawyDepartment of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia. f_altalbawy@yahoo.com.
Anaheed Hussein KareemCollege of Health and Medical Technology, Al-Ayen University, Thi-Qar, 64001, Iraq.
Hamza Fadhel HamzahDepartment of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
Bahira Abdulrazzaq MohammedDepartment of Technical Engineering, Al-Hadi University College, Baghdad, 10011, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of the nuclear paraspeckle assembly transcript 1 (NEAT1), as a well-known long non-coding RNA (lncRNA), is often upregulated in varied types of cancers and associated with poor survival outcomes in patients suffering from tumors. NEAT1 promotes the tumors growth by influencing the various genes' expression profile that regulate various aspects of tumor cell behavior, in particular tumor growth, metastasis and drug resistance. This suggests that NEAT1 are capable of serving as a new diagnostic biomarker and target for therapeutic intervention. Through interrelation with enhancer of zeste homolog 2 (EZH2), NEAT1 acts as a scaffold RNA molecule, and thus regulating the expression EZH2-associated genes. Additionally, by perform as miRNA sponge, it constrains suppressing the interactions between miRNAs-mediated degradation of target mRNAs. In light of this, NEAT1 inhibition by small interfering RNA (siRNA) hampers tumorgenesis. We summarize recent findings about the expression, biological functions, and regulatory process of NEAT1 in human tumors. It specifically emphasizes the clinical significance of NEAT1 as a novel diagnostic biomarker and a promising therapeutic mark for many types of cancers.

Indexed as

Enhancer of Zeste Homolog 2 ProteinNeoplasmsRNA, Long NoncodingBiomarkers, TumorCarcinogenesisGene Expression Regulation, NeoplasticHumansMicroRNAsNeoplasm MetastasisRNA, Small InterferingBiomarkers, TumorEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanMicroRNAsNEAT1 long non-coding RNA, humanRNA, Long NoncodingRNA, Small InterferingCancerLncRNANEAT1ProgressionTherapy

Identifiers

PMID38750383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.