ArticleNature2024
GLP-1-directed NMDA receptor antagonism for obesity treatment.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Investigating the functional connectivity between central glucagon-like peptide-1 (GLP-1) and glutamatergic signaling: a systematic review.CNS spectrums · 2026Pooled it
- Glucagon-like peptide-1 (GLP-1) receptor agonists for headache and pain disorders: a systematic review.The journal of headache and pain · 2024Pooled it
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- Article
- Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment.Acta pharmacologica Sinica · 2026Article
- The evolving landscape of obesity pharmacotherapy.Nature reviews. Drug discovery · 2026Review
- Semaglutide alters behaviour and nucleus accumbens oscillatory activity in healthy mice.Molecular brain · 2026Article
- N-Methyl-D-aspartate receptors: structure, signaling and roles in atherosclerosis.Journal of translational medicine · 2026Review
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026Review
- Article
- An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling.Science advances · 2026Article
- Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap.EBioMedicine · 2026Article
- Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals.medRxiv : the preprint server for health sciences · 2026Article
- Glucagon-Like Peptide-1: The Role of Calcium in Gut-Glucose Axis.Advances in experimental medicine and biology · 2026Review
- Article
- Fundamental role of brain-organ interaction in behavior-driven holistic homeostasis.Fundamental research · 2025Review
- AI-Driven De Novo Design of Ultra Long-Acting GLP-1 Receptor Agonists.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mechanisms of metabolic surgery effectiveness in obesity and type 2 diabetes: a puzzle with some known pieces.International journal of obesity (2005) · 2025Review
- GLP-1 receptor agonism results in reduction in hepatic ethanol metabolism.npj metabolic health and disease · 2025Article
Corrections and comments
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Authors and funding
33 authors.
Jonas PetersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6219-0271
Mette Q LudwigNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7814-3859
Vaida JuozaityteNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pablo Ranea-RoblesNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6478-3815
Charlotte SvendsenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8329-319X
Eunsang HwangCenter for Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
Amalie W KristensenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nicole FadahunsiNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jens LundNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2338-6033
Alberte W BreumNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8399-4308
Cecilie V MathiesenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8325-5898
Luisa SachsNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Roger Moreno-JusticiaNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8587-4772
Rebecca RohlfsNovo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.
James C FordNovo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.
Jonathan D DourosNovo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.
Brian FinanNovo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.ORCID 0000-0002-6467-0447
Bryan PortilloCenter for Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
Kyle GroseCenter for Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
Jacob E PetersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mette TrauelsenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6908-106X
Annette FeuchtingerCore Facility Pathology & Tissue Analytics, Helmholtz Munich, Neuherberg, Germany.
Richard D DiMarchiDepartment of Chemistry, Indiana University, Bloomington, IN, USA.ORCID 0000-0003-0220-4085
Thue W SchwartzNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0261-6904
Atul S DeshmukhNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2278-1843
Morten B ThomsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kristi A KohlmeierDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0183-3816
Kevin W WilliamsCenter for Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
Tune H PersNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0207-4831
Bente FrølundDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kristian StrømgaardDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anders B KleinNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0236-3089
Christoffer ClemmensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. chc@sund.ku.dk.ORCID 0000-0003-2456-9667
Funding
Ventromedial Hypothalamic Regulation of Metabolic Changes Induced by ExerciseP01DK119130 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ELMQUIST, JOEL K. · 2019 to 2023
$10.0MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4MCellular and Synaptic Reorganization after Exercise TrainingR01DK119169 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2018 to 2021
$1.6MAcute and chronic effects of GLP-1R agonism on NPY/AgRP neuronal activityR56DK135501 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2024 to 2024
$410kNIDDK NIH HHS P01 DK119130NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK119169NIDDK NIH HHS R56 DK135501
Abstract
The N-methyl-D-aspartate (NMDA) receptor is a glutamate-activated cation channel that is critical to many processes in the brain. Genome-wide association studies suggest that glutamatergic neurotransmission and NMDA receptor-mediated synaptic plasticity are important for body weight homeostasis
Indexed as
Dizocilpine MaleateGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsObesityReceptors, N-Methyl-D-AspartateAnimalsBrain StemDisease Models, AnimalDyslipidemiasHumansHyperglycemiaHypothalamusMaleMiceMice, Inbred C57BLDizocilpine MaleateGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsReceptors, N-Methyl-D-Aspartate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.