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ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2024

Access to melanoma drugs in Spain: a cross-sectional survey.

Maria Gonzalez-Cao, Teresa Puertolas, Jose Luis Manzano, Cayetana Maldonado, Oriol Yelamos, Miguel Ángel Berciano-Guerrero, Pablo Cerezuela, Juan Martin-Liberal, Eva Muñoz-Couselo, Enrique Espinosa and 8 more

Abstract read
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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Exploring uncertainties in melanoma management: a Spanish multidisciplinary Delphi consensus.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. AnInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Maria Gonzalez-CaoTranslational Cancer Research Unit, Instituto Oncologico Dr Rosell, Dexeus University Hospital, C/Sabino Arana, 5, 080028, Barcelona, Spain. mgonzalezcao@oncorosell.com.ORCID http://orcid.org/0000-0003-3791-540X
Teresa PuertolasOncology Department, Hospital Miguel Servet, Saragossa, Spain.
Jose Luis ManzanoOncology Department, Hospital Germans Trias I Pujol, Badalona, Spain.
Cayetana MaldonadoDermatology Department, Hospital Universitario de Asturias, Oviedo, Spain.
Oriol YelamosDermatology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Miguel Ángel Berciano-GuerreroOncology Department Hospitales, Universitarios Regional y Virgen de La Victoria (HURyVV), Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Málaga, Spain.
Pablo CerezuelaOncology Department, Hospital Clínico Universitario Virgen de La Arrixaca, Instituto Murciano de Investigación Biosanitaria (IMIB), Ciudad de Murcia, Murcia, Spain.
Juan Martin-LiberalCatalan Institute of Oncology (ICO) Hospitalet, Barcelona, Spain.
Eva Muñoz-CouseloOncology Department, Hospital Valle Hebron, Barcelona, Spain.
Enrique EspinosaOncology Department, Hospital Universitario La Paz, Madrid, Spain.
Ana DrozdowskyjTranslational Cancer Research Unit, Instituto Oncologico Dr Rosell, Dexeus University Hospital, C/Sabino Arana, 5, 080028, Barcelona, Spain.
Alfonso BerrocalOncology Department, Hospital General de Valencia, Valencia, Spain.
Ainara SoriaOncology Department, Hospital Ramon y Cajal, Madrid, Spain.
Ivan Marquez-RodasOncology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain.
Salvador Martin-AlgarraOncology Department, Clinica Universidad de Navarra, Pamplona, Spain.
Maria QuindosMedical Oncology Department, Complexo Hospitalario Universitario de A Coruña. Biomedical Research Institute (INIBIC), A Coruña, Spain.
Susana PuigCIBERER, Barcelona, Spain. spuig@clinic.cat.
Spanish Melanoma Group (GEM)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe development of highly active drugs has improved the survival of melanoma patients, but elevated drug prices place a significant burden on health care systems. In Spain, the public health care system is transferred to the 17 autonomous communities (AACC). The objective of this study is to describe the situation of drug access for melanoma patients in Spain and how this decentralized system is affecting equity.

methodsFrom July to September 2023, a cross-sectional survey was sent to members of the Spanish Multidisciplinary Melanoma Group (GEM Group). The questionnaire consulted about the real access to new drugs in each hospital. The responses were collected anonymously and analyzed according to several variables, including the AACC.

resultsThe survey was answered by 50 physicians in 15 AACC. No major differences on access between AACC were observed for indications that are reimbursed by the Spanish Health Care System (adjuvant immunotherapy for stage IIIC-IIID and resected stage IV melanoma). Important differences in drug access were observed among AACC and among centers within the same AACC, for most of the EMA indications that are not reimbursed (adjuvant immunotherapy for stages IIB-IIC-IIIA-IIIB) or that are not fully reimbursed (ipilimumab plus nivolumab in advanced stage). Homogeneously, access to adjuvant targeted drugs, TIL therapy and T-VEC, is extremely low or non-existing in all AACC.

conclusionsFor most indications that reimbursement is restricted out of the EMA indication, a great diversity on access was found throughout the different hospitals in Spain, including heterogeneity intra-AACC.

Indexed as

Health Services AccessibilityMelanomaAntineoplastic AgentsCross-Sectional StudiesHumansImmunotherapyIpilimumabNivolumabSkin NeoplasmsSpainSurveys and QuestionnairesAntineoplastic AgentsIpilimumabNivolumabAccessInnovative therapiesMelanoma

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.