Evidence map›Paper›PMID 38750307›Full record

ArticleEMBO molecular medicine2024

A broadly applicable protein-polymer adjuvant system for antiviral vaccines.

Caiqian Wang, Yuanyuan Geng, Haoran Wang, Zeheng Ren, Qingxiu Hou, An Fang, Qiong Wu, Liqin Wu, Xiujuan Shi, Ming Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. CXCL13 promotes broad immune responses induced by circular RNA vaccines.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Caiqian Wang *National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Yuanyuan Geng *College of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Haoran WangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Zeheng RenNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Qingxiu HouNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
An FangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Qiong WuNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.ORCID http://orcid.org/0000-0003-1922-420X
Liqin WuNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Xiujuan ShiCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Ming ZhouNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.ORCID http://orcid.org/0000-0001-7012-017X
Zhen F FuNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.ORCID http://orcid.org/0000-0001-6293-9329
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. jflovell@buffalo.edu.ORCID http://orcid.org/0000-0002-9052-884X
Honglin JinCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China. jin@hust.edu.cn.ORCID http://orcid.org/0000-0002-4398-9539
Ling ZhaoNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China. lingzhao@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0003-0569-8105

Funding

MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 2662023PY005MOST | National Key Research and Development Program of China (NKPs) No. 2022YFD1800100
6 · The paper itself

Abstract

Although protein subunit vaccines generally have acceptable safety profiles with precise antigenic content, limited immunogenicity can lead to unsatisfactory humoral and cellular immunity and the need for vaccine adjuvants and delivery system. Herein, we assess a vaccine adjuvant system comprising Quillaja Saponaria-21(QS-21) and cobalt porphyrin polymeric micelles that enabling the display of His-tagged antigen on its surface. The nanoscale micelles promote antigen uptake and dendritic cell activation to induce robust cytotoxic T lymphocyte response and germinal center formation. Using the recombinant protein antigens from influenza A and rabies virus, the micelle adjuvant system elicited robust antiviral responses and protected mice from lethal challenge. In addition, this system could be combined with other antigens to induce high titers of neutralizing antibodies in models of three highly pathogenic viral pathogens: Ebola virus, Marburg virus, and Nipah virus. Collectively, our results demonstrate this polymeric micelle adjuvant system can be used as a potent nanoplatform for developing antiviral vaccine countermeasures that promote humoral and cellular immunity.

Indexed as

Viral VaccinesAdjuvants, ImmunologicAdjuvants, VaccineAnimalsAntibodies, ViralDendritic CellsFemaleInfluenza A virusMiceMice, Inbred BALB CMice, Inbred C57BLMicellesPolymersRabies virusAdjuvants, ImmunologicAdjuvants, VaccineAntibodies, ViralMicellesPolymersViral VaccinesAntigen DeliveryAntiviral VaccineMultivalent DisplayNanovaccineRecombinant Protein Antigens

Identifiers

PMID38750307
PMCPMC11178928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.