Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21.

Keisuke Kobayashi, Rio Tejima, Kenichiro Nagai, Reiko Seki, Tsuyoshi Hosoya, Yumi Une, Satoru Shigeno, Hiroshi Tomoda, Taichi Ohshiro

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Article in The Journal of antibiotics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

9 authors.

Keisuke Kobayashi *Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.ORCID 0000-0001-9580-2484

Rio Tejima *Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Kenichiro NagaiMedicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Reiko SekiMedicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Tsuyoshi HosoyaDepartment of Botany, National Museum of Nature and Science, 4-4-1 Amakubo, Tsukuba, Ibaraki, 305-0005, Japan.

Yumi UneLaboratory of Veterinary Pathology, Okayama University of Science, 1-3 Ikoinooka, Imabari, Ehime, Japan.

Satoru ShigenoDepartment of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.ORCID 0009-0006-6528-8975

Hiroshi TomodaDepartment of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Taichi OhshiroDepartment of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. ohshirot@pharm.kitasato-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two new cyclic dipeptides, paranazzamides A (1) and B (2) containing a C7-prenylated tryptophan, were isolated from a culture broth of snake fungal disease-isolate Paranannizziopsis sp. UH-21. This is the first report on the new secondary metabolites from Paranannizziopsis sp. The planar structures of 1 and 2 were elucidated using various spectroscopic techniques including MS and 1D/2D NMR. The absolute configuration of 1 was assigned by comparison with the synthesized compound. Compounds 1 and 2 exhibited no antifungal activity, no antibacterial activity, and no cytotoxic activity even at a concentration of 128 µg ml

Indexed as

DipeptidesPeptides, CyclicTryptophanAmphotericin BAnimalsAnti-Bacterial AgentsAntifungal AgentsCandidaHumansMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolecular StructurePrenylationAmphotericin BAnti-Bacterial AgentsAntifungal AgentsDipeptidesPeptides, CyclicTryptophan

Identifiers

PMID38750250

DOI10.1038/s41429-024-00725-3

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.