Evidence map›Paper›PMID 38750160›Full record

ArticleEuropean journal of nutrition2024

Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model.

Angela M Laevski, Mélina R Doucet, Marco S Doucet, Audrée A LeBlanc, Paskale E Pineau, Mathieu P A Hébert, Jérémie A Doiron, Patrick Roy, Maroua Mbarik, Alexis J Matthew and 3 more

Abstract read
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Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Angela M Laevski *Department of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Mélina R Doucet *Department of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Marco S DoucetDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Audrée A LeBlancDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Paskale E PineauDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Mathieu P A HébertDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Jérémie A DoironDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Patrick RoyDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Maroua MbarikDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Alexis J MatthewDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Eric P AllainDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada.
Marc E SuretteDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada. marc.surette@umoncton.ca.
Luc H BoudreauDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, E1A 3E9, Canada. luc.boudreau@umoncton.ca.ORCID http://orcid.org/0000-0002-3674-5026

Funding

CIHR 165965CIHR 190390
6 · The paper itself

Abstract

purposeThe aim of this study was to investigate the effects of different ω-3 polyunsaturated fatty acid (PUFA) enriched diets, including a novel renewable plant source of ω-3 fatty acids (Buglossoides arvensis), on the development and progression of rheumatoid arthritis (RA).

methodsRA was induced in mice consuming experimental diets using the K/BxN model. The experimental diets consisted of either a western control diet (control), diets containing B. arvensis oil or fish oil. The effects of the diets on platelets, platelet microvesicles (PMVs), and inflammatory markers such as clinical index, ankle thickness and cytokine/chemokine release were measured.

resultsWhile ω-3 PUFA-enriched diets did not prevent the development of arthritis in the K/BxN model, a significant decrease in ankle swelling was observed compared to the control group. Platelets isolated from mice consuming either low content of B. arvensis oil or fish oil diets exhibited significantly decreased PMVs production compared to mice consuming the control diet.

conclusionOur study provides insight into the contribution of ω-3 PUFA supplementation in modulating the pro-inflammatory phenotype of platelets in RA pathology. Furthermore, our study suggests that low concentrations of dietary B. arvensis oil may have similar anti-inflammatory potential seen with dietary fish oil supplementation.

Indexed as

Arthritis, RheumatoidBlood PlateletsCell-Derived MicroparticlesDisease Models, AnimalFatty Acids, Omega-3Fish OilsAnimalsArthritis, ExperimentalCytokinesDietDietary SupplementsMaleMiceMice, Inbred C57BLCytokinesFatty Acids, Omega-3Fish OilsExtracellular vesiclesInflammationInflammatory arthritisPlatelet activationPlatelets

Identifiers

PMID38750160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.