ArticleScientific reports2024
CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Harnessing the sparing effect of FLASH-RT: From phenomenon observation, radiophysical determinants to molecular mechanisms and synergistic strategies.Materials today. Bio · 2026Review
- Multiscale Radiobiological Assessment of Laser-Driven Very High Energy Electrons Versus Conventional Electrons.Advances in radiation oncology · 2026Article
- Treatment planning comparison of focused very high energy electron and volumetric modulated arc therapy.Physics and imaging in radiation oncology · 2026Article
- Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype.Nature communications · 2025Article
- Review
- Comparative treatment planning of very high-energy electrons and photon volumetric modulated arc therapy: Optimising energy and beam parameters.Physics and imaging in radiation oncology · 2025Article
- Optimizing focused very-high-energy electron beams for radiation therapy based on Monte Carlo simulation.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. This paper presents an in depth exploration of the focusing achievable at the current CLEAR (CERN Linear Electron Accelerator for Research) facility, for beam energies >200 MeV. A shorter, more optimal quadrupole setup was also investigated using the TOPAS code in Monte Carlo simulations, with dimensions and beam parameters more appropriate to a clinical situation. This work provides insight into how a focused VHEE radiotherapy beam delivery system might be achieved.
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Registered trials
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