Evidence map›Paper›PMID 38750089›Full record

ArticleScientific reports2024

Dysregulation of platelet serotonin, 14-3-3, and GPIX in sudden infant death syndrome.

Andrew L Frelinger, Robin L Haynes, Richard D Goldstein, Michelle A Berny-Lang, Anja J Gerrits, Molly Riehs, Elisabeth A Haas, Brankica Paunovic, Othon J Mena, Steven C Campman and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Platelet Pathophysiology: Unexpected New Research Directions.Seminars in thrombosis and hemostasis · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrew L Frelinger *Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA. Andrew.Frelinger@childrens.harvard.edu.
Robin L Haynes *Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Richard D GoldsteinRobert's Program on Sudden Unexpected Death in Pediatrics, Division of General Pediatrics, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, USA.
Michelle A Berny-LangCenter for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.
Anja J GerritsCenter for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.
Molly RiehsDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Elisabeth A HaasRady Children's Hospital, San Diego, CA, USA.
Brankica PaunovicCounty of San Diego Medical Examiner's Office, San Diego, CA, USA.
Othon J MenaCounty of Ventura Medical Examiner's Office, Ventura, CA, USA.
Steven C CampmanCounty of San Diego Medical Examiner's Office, San Diego, CA, USA.
Ginger L MilneDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA.
Lynn A SleeperDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Hannah C KinneyDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Alan D MichelsonCenter for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.

Funding

VENTRAL MEDULLA, BREATHING, AND CENTRAL CHEMORECEPTIONP01HD036379 · NICHD · HARVARD MEDICAL SCHOOL · PI COMMONS, KATHRYN G · 1998 to 2017
$32.2M
SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI WOOLF, CLIFFORD J · 1985 to 2015
$26.2M
BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROMER01HD020991 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI HAYNES, ROBIN LYNN, KINNEY, HANNAH CHASE · 1986 to 2015
$3.3M
Genetics of Sudden Unexpected Death in PediatricsR21HD096355 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI GOLDSTEIN, RICHARD DANIEL, HOLM, INGRID ADELE · 2018 to 2019
$487k
Eunice Kennedy Shriver National Institute of Child Health and Development Grants P01-HD036379Eunice Kennedy Shriver National Institute of Child Health and Development Grants P30-HD18655Eunice Kennedy Shriver National Institute of Child Health and Development Grants R01-HD020991Eunice Kennedy Shriver National Institute of Child Health and Development Grants R21-HD096355NICHD NIH HHS P01 HD036379NICHD NIH HHS P30 HD018655NICHD NIH HHS R01 HD020991NICHD NIH HHS R21 HD096355
6 · The paper itself

Abstract

Sudden infant death syndrome (SIDS) is the leading cause of post-neonatal infant mortality, but the underlying cause(s) are unclear. A subset of SIDS infants has abnormalities in the neurotransmitter, serotonin (5-hydroxytryptamine [5-HT]) and the adaptor molecule, 14-3-3 pathways in regions of the brain involved in gasping, response to hypoxia, and arousal. To evaluate our hypothesis that SIDS is, at least in part, a multi-organ dysregulation of 5-HT, we examined whether blood platelets, which have 5-HT and 14-3-3 signaling pathways similar to brain neurons, are abnormal in SIDS. We also studied platelet surface glycoprotein IX (GPIX), a cell adhesion receptor which is physically linked to 14-3-3. In infants dying of SIDS compared to infants dying of known causes, we found significantly higher intra-platelet 5-HT and 14-3-3 and lower platelet surface GPIX. Serum and plasma 5-HT were also elevated in SIDS compared to controls. The presence in SIDS of both platelet and brainstem 5-HT and 14-3-3 abnormalities suggests a global dysregulation of these pathways and the potential for platelets to be used as a model system to study 5-HT and 14-3-3 interactions in SIDS. Platelet and serum biomarkers may aid in the forensic determination of SIDS and have the potential to be predictive of SIDS risk in living infants.

Indexed as

14-3-3 ProteinsBlood PlateletsPlatelet Glycoprotein GPIb-IX ComplexSerotoninSudden Infant DeathFemaleHumansInfantInfant, NewbornMale14-3-3 Proteinsadhesion receptorPlatelet Glycoprotein GPIb-IX ComplexSerotonin

Identifiers

PMID38750089
PMCPMC11096399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.