Evidence map›Paper›PMID 38750030›Full record

ArticleNature communications2024

An antiplasmid system drives antibiotic resistance gene integration in carbapenemase-producing Escherichia coli lineages.

Pengdbamba Dieudonné Zongo, Nicolas Cabanel, Guilhem Royer, Florence Depardieu, Alain Hartmann, Thierry Naas, Philippe Glaser, Isabelle Rosinski-Chupin

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Genomic Diversity and Extended-SpectrumInternational journal of microbiology · 2026
    Article
  13. Review
  14. Circulation of polyclonal OXA-244-producingJAC-antimicrobial resistance · 2025
    Article
  15. Article
  16. Article
  17. The extended mobility of plasmids.Nucleic acids research · 2025
    Review
  18. Article
  19. Comparative Genomic Profiles ofMicroorganisms · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pengdbamba Dieudonné ZongoEcology and Evolution of Antibiotic Resistance Unit, Institut Pasteur, Paris, France.
Nicolas Cabanel *Ecology and Evolution of Antibiotic Resistance Unit, Institut Pasteur, Paris, France.
Guilhem Royer *Ecology and Evolution of Antibiotic Resistance Unit, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0001-9092-8336
Florence DepardieuUniversité Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-2680-0589
Alain HartmannUMR AgroEcologie 1347, INRAe, Université Bourgogne Franche-Comté, Dijon, France.ORCID http://orcid.org/0000-0001-6034-5068
Thierry NaasTeam ReSIST, INSERM UMR 1184, Paris-Saclay University, Le Kremlin-Bicêtre, France.ORCID http://orcid.org/0000-0001-9937-9572
Philippe GlaserEcology and Evolution of Antibiotic Resistance Unit, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0003-4156-2782
Isabelle Rosinski-ChupinEcology and Evolution of Antibiotic Resistance Unit, Institut Pasteur, Paris, France. isabelle.rosinski-chupin@pasteur.fr.ORCID http://orcid.org/0000-0002-5464-0949

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-10-LABX-62-IBEIDAgence Nationale de la Recherche (French National Research Agency) ANR-20-PAMR-0010
6 · The paper itself

Abstract

Plasmids carrying antibiotic resistance genes (ARG) are the main mechanism of resistance dissemination in Enterobacterales. However, the fitness-resistance trade-off may result in their elimination. Chromosomal integration of ARGs preserves resistance advantage while relieving the selective pressure for keeping costly plasmids. In some bacterial lineages, such as carbapenemase producing sequence type ST38 Escherichia coli, most ARGs are chromosomally integrated. Here we reproduce by experimental evolution the mobilisation of the carbapenemase bla

Indexed as

beta-LactamasesEscherichia coliPlasmidsAnti-Bacterial AgentsBacterial ProteinsChromosomes, BacterialDrug Resistance, BacterialEscherichia coli ProteinsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesEscherichia coli Proteins

Identifiers

PMID38750030
PMCPMC11096173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.