Evidence map›Paper›PMID 38750022›Full record

ArticleCell death & disease2024

The cell cycle regulator p16 promotes tumor infiltrated CD8

Xin Zhang, Jiajia Wang, Kun Tang, Yu Yang, Xiaowei Liu, Shengtao Yuan, Feng Guo, Lianjun Zhang, Kaili Ma

Abstract read
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Response to Kawamoto et al.EMBO reports · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Frontiers in genetics · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Molecular factors associated with lung cancer in people living with HIV.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin Zhang *National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China.
Jiajia Wang *National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China.
Kun Tang *National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China.
Yu YangNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China.
Xiaowei LiuNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China.
Shengtao YuanInstitute of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing, Jiangsu, China.
Feng GuoDepartment of Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China. guofeng27@gmail.com.
Lianjun ZhangNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China. zlj@ism.cams.cn.ORCID 0000-0001-9448-7718
Kaili MaNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China. mkl@ism.cams.cn.ORCID 0000-0003-4940-1692

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32100724National Natural Science Foundation of China (National Science Foundation of China) 82271775National Natural Science Foundation of China (National Science Foundation of China) 82350114
6 · The paper itself

Abstract

The therapeutic efficacy of adoptive T cell therapy is largely restricted by reduced viability and dysfunction of CD8

Indexed as

ApoptosisCD8-Positive T-LymphocytesCyclin-Dependent Kinase Inhibitor p16AnimalsCell DifferentiationGlycolysisHumansLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLReceptors, Antigen, T-CellT-Cell ExhaustionTumor MicroenvironmentCyclin-Dependent Kinase Inhibitor p16Receptors, Antigen, T-Cell

Identifiers

PMID38750022
PMCPMC11096187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.