Evidence map›Paper›PMID 38749732›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Young Patient with X-linked Agammaglobulinemia Presents with Advanced Gastric Cancer and Extensive Atrophic Gastritis.

Takashi Kon, Yu Sasaki, Yasuhiko Abe, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Minami Ito, Takahiro Watabe, Hiroko Tsuchiya, Hiroki Goto and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Revisiting X-linked agammaglobulinemia.Journal of human immunity · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Takashi KonDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Yu SasakiDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Yasuhiko AbeDivision of Endoscopy, Yamagata University Hospital, Japan.
Makoto YagiDivision of Endoscopy, Yamagata University Hospital, Japan.
Naoko MizumotoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Yusuke OnozatoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Minami ItoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Takahiro WatabeDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Hiroko TsuchiyaDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Hiroki GotoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Takahiro MiuraDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Ryo SatoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.
Yoshiyuki UenoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-linked agammaglobulinemia (XLA) is associated with an increased risk of gastrointestinal cancers including gastric cancer (GC). We herein report the case of a 30-year-old male patient with XLA who developed GC and extensive atrophic gastritis. He tested positive in the urea breath test, thus indicating the presence of Helicobacter pylori. Distal gastrectomy and chemotherapy were performed without any complications; however, the died two years after this diagnosis. Immunoglobulin deficiency makes these patients susceptible to progressive atrophic gastritis and the associated risk of GC. Therefore, patients with XLA are advised to undergo an evaluation for Helicobacter pylori infection as well as monitoring for GC.

Indexed as

AgammaglobulinemiaGastritis, AtrophicGenetic Diseases, X-LinkedHelicobacter InfectionsStomach NeoplasmsAdultFatal OutcomeGastrectomyHelicobacter pyloriHumansMaleatrophic gastritisgastric cancerH. pylori infectionX-linked agammaglobulinemia

Identifiers

PMID38749732
PMCPMC11781919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.