Evidence map›Paper›PMID 38749726›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Dupilumab-induced Diffuse Alveolar Hemorrhage.

Tomoki Tamura, Hiroya Okano, Taisaku Koyanagi, Takahiro Umeno, Kazuya Nishii, Shoichi Kuyama

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tomoki TamuraDepartment of Respiratory Medicine, NHO Iwakuni Clinical Center, Japan.
Hiroya OkanoDepartment of Respiratory Medicine, NHO Iwakuni Clinical Center, Japan.
Taisaku KoyanagiDepartment of Respiratory Medicine, NHO Iwakuni Clinical Center, Japan.
Takahiro UmenoDepartment of Respiratory Medicine, NHO Iwakuni Clinical Center, Japan.
Kazuya NishiiDepartment of Respiratory Medicine, NHO Iwakuni Clinical Center, Japan.
Shoichi KuyamaDepartment of Respiratory Medicine, NHO Iwakuni Clinical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosinophilic pneumonia is a known side effect of dupilumab; however, diffuse alveolar hemorrhage has not yet been reported in association with dupilumab. We herein report a case of diffuse alveolar hemorrhage caused by dupilumab. A 57-year-old man with severe asthma was unable to discontinue oral steroids and thus was prescribed dupilumab. The patient was admitted to the hospital four weeks after treatment because of suspected eosinophilic pneumonia. Bronchoscopy revealed diffuse alveolar hemorrhage characterized by hemosiderin-phagocytic macrophages in the bronchoalveolar lavage fluid without eosinophils. The steroid dosage improved the respiratory status and resolved the infiltrate shadow. Dupilumab may thus cause diffuse alveolar hemorrhage, which can be differentiated using bronchoscopy.

Indexed as

Antibodies, Monoclonal, HumanizedHemorrhagePulmonary AlveoliAsthmaBronchoscopyHumansLung DiseasesMaleMiddle AgedPulmonary EosinophiliaAntibodies, Monoclonal, Humanizeddupilumabasthmabronchoalveolar lavagediffuse alveolar hemorrhagedupilumab

Identifiers

PMID38749726
PMCPMC11781931

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.