Evidence map›Paper›PMID 38749701›Full record

ArticleeNeuro2024

Altered Hippocampal Activation in Seizure-Prone

Alyssa B Danis, Ashlynn A Gallagher, Ashley N Anderson, Arielle Isakharov, Kathleen A Beeson, Eric Schnell

Abstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Alyssa B DanisDepartment of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239.
Ashlynn A GallagherDepartment of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239.ORCID https://orcid.org/0009-0002-9918-5174
Ashley N AndersonDepartment of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239.ORCID https://orcid.org/0009-0005-1769-3792
Arielle IsakharovNeuroscience Graduate Program, Oregon Health & Science University, Portland, Oregon 97239.ORCID https://orcid.org/0000-0002-9706-7871
Kathleen A BeesonNeuroscience Graduate Program, Oregon Health & Science University, Portland, Oregon 97239.ORCID https://orcid.org/0000-0002-4392-3265
Eric SchnellDepartment of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239 schneler@ohsu.edu.ORCID https://orcid.org/0000-0002-5623-5015

Funding

Alpha2delta-mediated control of neuronal signalingR01NS126247 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Eric Schnell · 2022 to 2026
$1.7M
Microglial control of post-ischemic neurogenesisR21NS102948 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI KOERNER, INES PIA, SCHNELL, ERIC · 2018 to 2019
$418k
Control of Circuit Hyperexcitability by Endogenous Opioids in EpilepsyI01BX004938 · VA · PORTLAND VA MEDICAL CENTER · PI SCHNELL, ERIC · 2020 to 2023
–
BLRD VA I01 BX004938NINDS NIH HHS R01 NS126247NINDS NIH HHS R21 NS102948
6 · The paper itself

Abstract

The voltage-gated calcium channel subunit α2δ-2 controls calcium-dependent signaling in neurons, and loss of this subunit causes epilepsy in both mice and humans. To determine whether mice without α2δ-2 demonstrate hippocampal activation or histopathological changes associated with seizure activity, we measured expression of the activity-dependent gene c

Indexed as

Calcium ChannelsHippocampusMice, KnockoutProto-Oncogene Proteins c-fosSeizuresAnimalsConvulsantsDisease Models, AnimalMiceMice, Inbred C57BLNeuronsPentylenetetrazoleCacna2d2 protein, mouseCalcium ChannelsConvulsantsPentylenetetrazoleProto-Oncogene Proteins c-fosalpha-2-deltacalcium channelsdentate gyrusepilepsyhippocampus

Identifiers

PMID38749701
PMCPMC11097259

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.