Evidence map›Paper›PMID 38749559›Full record

ArticleThe Journal of rheumatology2024

Ambulatory Blood Pressure in Patients With Rheumatoid Arthritis: Association With Immune Activation.

Michelle J Ormseth, Annette M Oeser, Cecilia P Chung, C Michael Stein

Abstract read
In one paragraph

Article in The Journal of rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Metabolic Consequences of Rheumatoid Arthritis.Arthritis care & research · 2025
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michelle J OrmsethM.J. Ormseth, MD, MSCI, Department of Medicine, Vanderbilt University Medical Center, and Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee; Michelle.ormseth@vumc.org.ORCID 0000-0003-3734-3309
Annette M OeserA.M. Oeser, BS, MLAS, C.M. Stein, MD, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Cecilia P ChungC.P. Chung, MD, Department of Medicine, University of Miami Health System, and Miami VA Healthcare System, Miami, Florida, USA.
C Michael SteinA.M. Oeser, BS, MLAS, C.M. Stein, MD, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Salt, Blood Pressure, and InflammationR01HL140145 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STEIN, CHARLES M. · 2018 to 2021
$2.3M
2-HOBA Phase 2 Clinical Trial in Rheumatoid ArthritisR21AR080372 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ORMSETH, MICHELLE JANE · 2022 to 2024
$576k
NCATS NIH HHS UL1 TR002243NHLBI NIH HHS R01 HL140145NIAMS NIH HHS R21 AR080372
6 · The paper itself

Abstract

objectiveThe prevalence of hypertension, a major cardiovascular risk factor, is increased in patients with rheumatoid arthritis (RA) and may be driven by immune activation. The purpose of this study was to determine if ambulatory 24-hour blood pressure (BP) is elevated in RA vs control participants and whether it is associated with immune activation.

methodsWe conducted a cross-sectional study of 46 patients with RA and 23 control participants. Participants wore an ambulatory BP monitor that obtained diurnal BP every 15-30 minutes and nocturnal BP every 30 minutes. Inflammatory mediators in plasma were measured using an inflammation proteomics panel. Differences in BP measurements were assessed by Mann-Whitney

resultsPatients with RA and control participants had similar office BP, but median ambulatory systolic BP (SBP) measurements (24-hour [RA 121 mmHg vs control 116 mmHg;

conclusionDespite similar office measurements, 24-hour and nocturnal SBP measurements were higher in patients with RA than in control participants and were strongly associated with inflammation.

Indexed as

Arthritis, RheumatoidBlood PressureBlood Pressure Monitoring, AmbulatoryHypertensionAdultAgedCircadian RhythmCross-Sectional StudiesFemaleHumansMaleMiddle Agedcardiovascular diseasehypertensioninflammationrheumatoid arthritis

Identifiers

PMID38749559
PMCPMC11368629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.