Evidence map›Paper›PMID 38749511›Full record

ArticleBMJ global health2024

Long-term healthcare utilisation, costs and quality of life after invasive group B

Farah Seedat, Simon Procter, Ziyaad Dangor, Shannon Leahy, Sridhar Santhanam, Hima B John, Quique Bassat, Celine Aerts, Amina Abubakar, Carophine Nasambu and 9 more

Abstract read
In one paragraph

Article in BMJ global health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Farah SeedatDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK fseedat@sgul.ac.uk.ORCID http://orcid.org/0000-0002-3563-7875
Simon ProcterDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0002-0380-1503
Ziyaad DangorMedical Research Council: Vaccines and Infectious Diseases Analytical Unit, Faculty of Health Sciences, University of the Witwatersrand Johannesburg, Johannesburg, Gauteng, South Africa.
Shannon LeahyDepartment of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand Johannesburg, Johannesburg, Gauteng, South Africa.
Sridhar SanthanamNeonatology Department, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Hima B JohnNeonatology Department, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Quique BassatCentro de Investigação em Saúde de Manhiça, Manhica, Maputo, Mozambique.ORCID http://orcid.org/0000-0003-0875-7596
Celine AertsHospital Clínic, Universitat de Barcelona, ISGlobal, Barcelona, Spain.
Amina AbubakarNeuroscience Research Group, Department of Clinical Sciences, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Carophine NasambuNeuroscience Research Group, Department of Clinical Sciences, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Romina LibsterFundación Infant, Buenos Aires, Argentina.
Clara Sánchez YanottiFundación Infant, Buenos Aires, Argentina.
Proma PaulDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Jaya ChandaDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Bronner P GonçalvesDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Erzsébet Horváth-PuhóDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
Joy E LawnDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
GBS Long-Term Outcomes LMIC Collaborative Group
Mark JitDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

introductionThere are no published data on the long-term impact of invasive group B

methodsInpatient and outpatient visits, out-of-pocket (OOP) healthcare payments in the 12 months before study enrolment, and health-state utility of children and caregivers (using the EuroQol 5-Dimensions-3-Level) were collected from iGBS survivors and an unexposed cohort matched on site, age at recruitment and sex. We used logistic or Poisson regression for analysing healthcare utilisation and zero-inflated gamma regression models for family and health system costs. For HRQoL, we used a zero-inflated beta model of disutility pooled data.

results161 iGBS-exposed and 439 unexposed children and young adults (age 1-20) were included in the analysis. Compared with unexposed participants, iGBS was associated with increased odds of any healthcare utilisation in India (adjusted OR 11.2, 95% CI 2.9 to 43.1) and Mozambique (6.8, 95% CI 2.2 to 21.1) and more frequent healthcare visits (adjusted incidence rate ratio (IRR) for India 1.7 (95% CI 1.4 to 2.2) and for Mozambique 6.0 (95% CI 3.2 to 11.2)). iGBS was also associated with more frequent days in inpatient care in India (adjusted IRR 4.0 (95% CI 2.3 to 6.8) and Kenya 6.4 (95% CI 2.9 to 14.3)). OOP payments were higher in the iGBS cohort in India (adjusted mean: Int$682.22 (95% CI Int$364.28 to Int$1000.16) vs Int$133.95 (95% CI Int$72.83 to Int$195.06)) and Argentina (Int$244.86 (95% CI Int$47.38 to Int$442.33) vs Int$52.38 (95% CI Int$-1.39 to Int$106.1)). For all remaining sites, differences were in the same direction but not statistically significant for almost all outcomes. Health-state disutility was higher in iGBS survivors (0.08, 0.04-0.13 vs 0.06, 0.02-0.10).

conclusionThe iGBS health and economic burden may persist for years after acute disease. Larger studies are needed for more robust estimates to inform the cost-effectiveness of iGBS prevention.

Indexed as

Developing CountriesQuality of LifeStreptococcal InfectionsAdolescentArgentinaChildChild, PreschoolCohort StudiesFemaleHealth Care CostsHumansIndiaInfantKenyaMaleMozambiqueChild healthCohort studyEpidemiologyInfections, diseases, disorders, injuries

Identifiers

PMID38749511
PMCPMC11097862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.