ArticleNature2024
Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Age-associated differences in XBB.1.5 trivalent booster vaccine-induced adaptive responses revealed by single-cell RNA sequencing.Emerging microbes & infections · 2026Article
- Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses.Journal of virology · 2026Article
- Article
- Potent type-specific de novo antibodies complement broadly reactive imprinted antibodies in immune responses to SARS-CoV-2 variants.Nature immunology · 2026Article
- Respiratory mucosal vaccines for emerging viruses: promise and challenges.Journal of virology · 2026Review
- Vaccination-first immune priming shapes a sustained mRNA vaccine-induced IgG4 class switch that associates with SARS-CoV-2 breakthrough infection risk.Scientific reports · 2026Article
- JN.1-adapted vaccination is associated with readjustment of ancestral memory B cells toward neutralization within the JN.1 antigenic space.Nature communications · 2026Article
- Intranasal boosting induces variant-specific responses in SARS-CoV-2 vaccine-imprinted mice.Nature communications · 2026Article
- Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine.medRxiv : the preprint server for health sciences · 2026Article
- A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines.Nature immunology · 2026Article
- Optimizing mouse models for mRNA vaccines: addressing dose translation challenges.Scientific reports · 2026Article
- Article
- Three Doses and Six Months Later: Real-World SARS-CoV-2 Specific Humoral and Cell-Mediated Immunity in Children With Inborn Errors of Immunity.Journal of clinical immunology · 2026Observational
- Enhancing, controlling, and sterilizing dengue immunity and the development of broadly protective responses.medRxiv : the preprint server for health sciences · 2026Article
- Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans.Cell reports · 2026Article
- Dose-dependent IFN programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination.JCI insight · 2026Article
- Impact of adjuvants on a recombinant SARS-CoV-2 spike vaccine: Protective efficacy and recall antibody response following homologous challenge.Biosafety and health · 2026Article
- Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution.Cell reports · 2026Article
- Assessment of SARS-CoV-2 immune escape using antigenic cartography combined with experimental challenge studies.NPJ vaccines · 2026Article
- Temporal dynamics of IgM and IgG after COVID-19 vaccination: a pilot cohort study on breakthrough infections.Clinical and experimental vaccine research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Chieh-Yu LiangDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-4624-7212
Saravanan RajuDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Zhuoming LiuDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-8198-0976
Yuhao LiDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-2413-0937
Guha Asthagiri ArunkumarModerna, Inc., Cambridge, MA, USA.ORCID 0000-0003-3665-2708
James Brett CaseDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-7331-5511
Suzanne M ScheafferDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Seth J ZostVanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-6712-5076
Cory M AcremanDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Matthew GagneVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5526-6162
Shayne F AndrewVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7226-7757
Deborah Carolina Carvalho Dos AnjosDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Kathryn E FouldsVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jason S McLellanDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0003-3991-542X
James E CroweVanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-0049-1079
Daniel C DouekVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5575-8634
Sean P J WhelanDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-1564-8590
Sayda M ElbashirModerna, Inc., Cambridge, MA, USA.
Darin K EdwardsModerna, Inc., Cambridge, MA, USA.ORCID 0000-0002-2065-2941
Michael S DiamondDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. mdiamond@wustl.edu.ORCID 0000-0002-8791-3165
Funding
COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4MNIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6MInnate and Adaptive Immune Responses in SARS-CoV-2 infection (COVID-19)ZIAAI005151 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DOUEK, DANIEL CESAR · 2020 to 2025
$6.8MHuman antibody-based countermeasures against the Wuhan Coronavirus SARS-CoV-2R01AI157155 · NIAID · WASHINGTON UNIVERSITY · PI BARIC, RALPH S, CROWE, JAMES E · 2020 to 2024
$6.0MNon-Human Primate Core for COVID EffortZICAI005164 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FOULDS, KATHRYN · 2020 to 2025
$1.3MNIAID NIH HHS 75N93019C00051NIAID NIH HHS 75N93021C00014NIAID NIH HHS R01 AI157155
Abstract
Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination
Indexed as
Antibodies, NeutralizingAntibodies, ViralCOVID-19COVID-19 VaccinesImmunization, SecondarymRNA VaccinesSARS-CoV-22019-nCoV Vaccine mRNA-1273AdultAnimalsChinaCross ReactionsEpitopes, B-LymphocyteFemaleHumansMale2019-nCoV Vaccine mRNA-1273Antibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesEpitopes, B-LymphocytemRNA VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.