Evidence map›Paper›PMID 38749416›Full record

ReviewBiofabrication2024

Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling.

Evelyn Zarate-Sanchez, Steven C George, Monica L Moya, Claire Robertson

Abstract readReview
In one paragraph

Review in Biofabrication, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Evelyn Zarate-SanchezDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States of America.
Steven C GeorgeDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States of America.
Monica L MoyaMaterials Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA, United States of America.
Claire RobertsonMaterials Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA, United States of America.ORCID 0000-0002-3059-5135

Funding

An Integrated In Vitro 3D Model of Human Bone Marrow and Peripheral InfectionR01EB030410 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GEORGE, STEVEN CARL · 2021 to 2024
$2.6M
NIBIB NIH HHS R01 EB030410
6 · The paper itself

Abstract

The hemorrhagic fever viruses (HFVs) cause severe or fatal infections in humans. Named after their common symptom hemorrhage, these viruses induce significant vascular dysfunction by affecting endothelial cells, altering immunity, and disrupting the clotting system. Despite advances in treatments, such as cytokine blocking therapies, disease modifying treatment for this class of pathogen remains elusive. Improved understanding of the pathogenesis of these infections could provide new avenues to treatment. While animal models and traditional 2D cell cultures have contributed insight into the mechanisms by which these pathogens affect the vasculature, these models fall short in replicating

Indexed as

Hemorrhagic Fevers, ViralAnimalsEndothelial CellsEndothelium, VascularHumansModels, Biologicalhemorrhagic fever virusesmicrophysiological systemsvasculotropic disease

Identifiers

PMID38749416
PMCPMC11151171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.