Evidence map›Paper›PMID 38748998›Full record

ArticleMedical physics2024

High spatiotemporal resolution scintillation imaging of pulsed pencil beam scanning proton beams produced by a gantry-mounted synchrocyclotron.

S Murty Goddu, Yao Hao, Zhen Ji, Jufri Setianegara, Fengwei Liu, Winter Green, Lee G Sobotka, Tianyu Zhao, Stephanie Perkins, Arash Darafsheh

Abstract read
In one paragraph

Article in Medical physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

S Murty GodduDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Yao HaoDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Zhen JiDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Jufri SetianegaraDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Fengwei LiuDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Winter GreenDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Lee G SobotkaDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri, USA.
Tianyu ZhaoDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Stephanie PerkinsDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Arash DarafshehDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0003-4148-0891

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Alvin J. Siteman Cancer CenterDepartment of Radiation OncologyFoundation for Barnes-Jewish HospitalNCI NIH HHS P30 CA091842S. Lee Kling Proton Therapy CenterWashington University School of Medicine in St. Louis
6 · The paper itself

Abstract

backgroundA dosimeter with high spatial and temporal resolution would be of significant interest for pencil beam scanning (PBS) proton beams' characterization, especially when facing small fields and beams with high temporal dynamics. Optical imaging of scintillators has potential in providing sub-millimeter spatial resolution with pulse-by-pulse basis temporal resolution when the imaging system is capable of operating in synchrony with the beam-producing accelerator. PURPOSE: We demonstrate the feasibility of imaging PBS proton beams as they pass through a plastic scintillator detector to simultaneously obtain multiple beam parameters, including proton range, pencil beam's widths at different depths, spot's size, and spot's position on a pulse-by-pulse basis with sub-millimeter resolution. MATERIALS AND

methodsA PBS synchrocyclotron was used for proton irradiation. A BC-408 plastic scintillator block with 30 × 30 × 5 cm

resultsScintillation images with 0.16 mm/pixel resolution corresponding to all proton pulses were captured. Pulse-by-pulse analysis showed that variations of the range, spots' position, and size were within ± 0.2% standard deviation of their average values. The absolute ranges were within ± 1 mm of their expected values. The average spot-positions were mostly within ± 0.8 mm and spots' sigma agreed within 0.2 mm of the expected values.

conclusionScintillation-imaging PBS beams with high-spatiotemporal resolution is feasible and may help in efficient and cost-effective acceptance testing and commissioning of existing and even emerging technologies such as FLASH, grid, mini-beams, and so forth.

Indexed as

Scintillation CountingCyclotronsFeasibility StudiesProtonsProton TherapyProtonsimagingproton therapyquality assurancescintillationsynchrocyclotron

Identifiers

PMID38748998
PMCPMC13160180

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.