Evidence map›Paper›PMID 38748794›Full record

ArticleScience advances2024

Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts.

Russell R Urie, Aaron Morris, Diana Farris, Elizabeth Hughes, Chengchuan Xiao, Judy Chen, Elizabeth Lombard, Jiane Feng, Jun Z Li, Daniel R Goldstein and 1 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Diagnostic and predictive biomarkers of acute rejection after liver transplantation.International journal of surgery (London, England) · 2025
    Review
  8. Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Russell R UrieDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2728-2541
Aaron MorrisDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4680-2493
Diana FarrisDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Elizabeth HughesDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0007-8345-8285
Chengchuan XiaoDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0007-8349-6273
Judy ChenDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-5469-6619
Elizabeth LombardDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0007-1204-1191
Jiane FengAnimal Phenotyping Core, University of Michigan, Ann Arbor, MI 48109, USA.
Jun Z LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6727-0812
Daniel R GoldsteinDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6695-979X
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9296-9673

Funding

Novel mechanisms of age-enhanced vasculopathy after heart transplantationR01AI138347 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDSTEIN, DANIEL ROBERT · 2018 to 2022
$2.7M
Immulogical Niches and Non-invasive Biosensors for Autoimmune MonitoringK99EB028840 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORRIS, AARON HARVEY · 2020 to 2021
$184k
Interrogating the Effects of Aging on Influenza Infections: The Role of Prostaglandin E2F31HL158003 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, JUDY · 2021 to 2023
$83k
NHLBI NIH HHS F31 HL158003NIAID NIH HHS R01 AI138347NIBIB NIH HHS K99 EB028840
6 · The paper itself

Abstract

Invasive graft biopsies assess the efficacy of immunosuppression through lagging indicators of transplant rejection. We report on a microporous scaffold implant as a minimally invasive immunological niche to assay rejection before graft injury. Adoptive transfer of T cells into Rag2

Indexed as

AllograftsBiomarkersGraft RejectionAnimalsHeart TransplantationMiceMice, Inbred C57BLMice, KnockoutSkin TransplantationSubcutaneous TissueTissue EngineeringTissue ScaffoldsT-LymphocytesBiomarkers

Identifiers

PMID38748794
PMCPMC11095459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.