Evidence map›Paper›PMID 38748789›Full record

ArticleScience advances2024

N-MYC impairs innate immune signaling in high-grade serous ovarian carcinoma.

Alex Miranda, Swetansu Pattnaik, Phineas T Hamilton, Monica Alvaro Fuss, Shreena Kalaria, Céline M Laumont, Julian Smazynski, Monica Mesa, Allyson Banville, Xinpei Jiang and 3 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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  6. Lactate and lactylation in tumor immunity.Frontiers of medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alex MirandaDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada.ORCID 0000-0002-3086-5326
Swetansu PattnaikThe Kinghorn Cancer Centre and Cancer Division, Garvan Institute of Medical Research, 370 Victoria St, Darlinghurst, NSW, Australia.ORCID 0000-0003-3598-7733
Phineas T HamiltonDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada.
Monica Alvaro FussDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada.ORCID 0009-0003-5391-7285
Shreena KalariaDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada.ORCID 0009-0006-5586-3462
Céline M LaumontDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada.ORCID 0000-0002-9067-4054
Julian SmazynskiDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada.
Monica MesaDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8P 3E6, Canada.
Allyson BanvilleDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada.ORCID 0000-0002-9289-4157
Xinpei JiangNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0003-2358-7580
Russell JenkinsMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6110-2148
Israel CañadasNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0001-6474-711X
Brad H NelsonDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada.ORCID 0000-0002-4445-5539

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-grade serous ovarian cancer (HGSC) is a challenging disease, especially for patients with immunologically "cold" tumors devoid of tumor-infiltrating lymphocytes (TILs). We found that HGSC exhibits among the highest levels of

Indexed as

Immunity, InnateN-Myc Proto-Oncogene ProteinOvarian NeoplasmsSignal TransductionAdaptor Proteins, Signal TransducingCell Line, TumorCystadenocarcinoma, SerousFemaleGene Expression Regulation, NeoplasticHumansInterferon Type IMembrane ProteinsNeoplasm GradingProto-Oncogene Proteins c-mycAdaptor Proteins, Signal TransducingInterferon Type IMembrane ProteinsMYCN protein, humanN-Myc Proto-Oncogene ProteinProto-Oncogene Proteins c-myc

Identifiers

PMID38748789
PMCPMC11095474

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.