Evidence map›Paper›PMID 38748762›Full record

SynthesisMovement disorders clinical practice2024

Movement Disorders in Patients with Subacute Sclerosing Panencephalitis: A Systematic Review.

Divyani Garg, Sahil Patel, Charulata S Sankhla, Vikram V Holla, Vijayashankar Paramanandam, Prashanth L Kukkle, Sanjay Pandey, Susanne A Schneider, Pramod K Pal

Abstract readSystematic Review
In one paragraph

Synthesis in Movement disorders clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Navigating diagnostic overlap between seizures and movement disorders: A practical clinical approach.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Divyani GargDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0003-0532-3370
Sahil PatelDepartment of Neurology, P. D. Hinduja National Hospital & Medical Research Centre, Mumbai, India.ORCID https://orcid.org/0000-0002-2951-9223
Charulata S SankhlaDepartment of Neurology, P. D. Hinduja National Hospital & Medical Research Centre, Mumbai, India.ORCID https://orcid.org/0000-0002-8864-5107
Vikram V HollaDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.ORCID https://orcid.org/0000-0002-3634-2219
Vijayashankar ParamanandamApollo Hospital, Chennai, India.ORCID https://orcid.org/0000-0003-1197-5308
Prashanth L KukkleParkinson's Disease and Movement Disorders Clinic, Bangalore, India.ORCID https://orcid.org/0000-0002-4610-947X
Sanjay PandeyDepartment of Neurology and Stroke Medicine, Amrita Institute of Medical Sciences, Faridabad, India.ORCID https://orcid.org/0000-0003-1771-9137
Susanne A SchneiderDepartment of Neurology, LMU University Hospital, Munich, Germany.ORCID https://orcid.org/0000-0001-7283-1995
Pramod K PalDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.ORCID https://orcid.org/0000-0002-4085-2377

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubacute sclerosing panencephalitis (SSPE) is a complication of measles, occurring after a latency of 4-10 years. It continues to occur in developing countries although resurgence is being reported from developed countries. Characteristic features include progressive neuropsychiatric issues, myoclonus, seizures, movement disorders and visual impairment. Electroencephalography (EEG) typically shows periodic generalized discharges, and elevated CSF anti-measles antibodies are diagnostic. Movement disorders are being increasingly recognized as part of the clinical spectrum, and range from hyperkinetic (chorea, dystonia, tremor, tics) to hypokinetic (parkinsonism) disorders and ataxia.

objectivesThis article aims to comprehensively review the spectrum of movement disorders associated with SSPE.

methodsA literature search was conducted in PubMed and EMBASE databases in December 2023 and articles were identified for review.

resultsMovement disorders reported in SSPE included hyperkinetic (chorea, dystonia, tremor and tics), hypokinetic (parkinsonism), ataxia and extraocular movement disorders. Myoclonus, a core clinical feature, was the most frequent "abnormal movement." Movement disorders were observed in all clinical stages, and could also be a presenting feature, even sans myoclonus. Hyperkinetic movement disorders were more common than hypokinetic movement disorders. An evolution of movement disorders was observed, with ataxia, chorea and dystonia occurring earlier, and parkinsonism later in the disease. Neuroradiological correlates of movement disorders remained unclear.

conclusionA wide spectrum of movement disorders was observed throughout the clinical stages of SSPE. Most data were derived from case reports and small case series. Multicentric longitudinal studies are required to better delineate the spectrum and evolution of movement disorders in SSPE.

Indexed as

Movement DisordersSubacute Sclerosing PanencephalitisChoreaDystoniaElectroencephalographyHumansMyoclonusTremorchoreameaslesmyoclonusparkinsonismSSPE

Identifiers

PMID38748762
PMCPMC11233848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.