Evidence map›Paper›PMID 38748582›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of

Sujeet Kumar, Rebecca M Davis, Natividad Ruiz

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. YdbL directly modulates YdbH-YnbE bridge formation to maintainbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sujeet KumarDepartment of Microbiology, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-8207-4358
Rebecca M DavisDepartment of Microbiology, The Ohio State University, Columbus, OH 43210.
Natividad RuizDepartment of Microbiology, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-6369-2206

Funding

Envelope Biogenesis in Gram-negative BacteriaR01GM100951 · NIGMS · OHIO STATE UNIVERSITY · PI RUIZ, NATIVIDAD · 2012 to 2023
$3.7M
Functional characterization of AsmA-like proteins in Escherichia coliR03AI139271 · NIAID · OHIO STATE UNIVERSITY · PI RUIZ, NATIVIDAD · 2018 to 2019
$156k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI139271HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM100951NIAID NIH HHS R03 AI139271NIGMS NIH HHS R01 GM100951
6 · The paper itself

Abstract

The outer membrane (OM) of didermic gram-negative bacteria is essential for growth, maintenance of cellular integrity, and innate resistance to many antimicrobials. Its asymmetric lipid distribution, with phospholipids in the inner leaflet and lipopolysaccharides (LPS) in the outer leaflet, is required for these functions. Lpt proteins form a transenvelope bridge that transports newly synthesized LPS from the inner membrane (IM) to OM, but how the bulk of phospholipids are transported between these membranes is poorly understood. Recently, three members of the AsmA-like protein family, TamB, YhdP, and YdbH, were shown to be functionally redundant and were proposed to transport phospholipids between IM and OM in

Indexed as

Bacterial Outer MembraneBacterial Outer Membrane ProteinsEscherichia coliEscherichia coli ProteinsHomeostasisCell MembraneLipopolysaccharidesLipoproteinsPhospholipidsBacterial Outer Membrane ProteinsEscherichia coli ProteinsLipopolysaccharidesLipoproteinsPhospholipidsAsmA-like proteinslipid transportmembrane contact sitesouter membrane biogenesistransenvelope complex

Identifiers

PMID38748582
PMCPMC11126948

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.