Evidence map›Paper›PMID 38748581›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

iATPSnFR2: A high-dynamic-range fluorescent sensor for monitoring intracellular ATP.

Jonathan S Marvin, Alexandros C Kokotos, Mukesh Kumar, Camila Pulido, Ariana N Tkachuk, Jocelyn Shuxin Yao, Timothy A Brown, Timothy A Ryan

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Learning Shapes the Energy Cost of Neural Tasks.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. NADThe EMBO journal · 2026
    Article
  13. Article
  14. Article
  15. Cerebral capillary computation.American journal of physiology. Cell physiology · 2026
    Review
  16. Inorganic phosphate and the rapid mobilization of metabolic energy in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonathan S MarvinHHMI, Ashburn, VA 20147.ORCID 0000-0003-2294-4515
Alexandros C KokotosDepartment of Biochemistry, Weill Cornell Medicine, New York, NY 10065.
Mukesh KumarDepartment of Biochemistry, Weill Cornell Medicine, New York, NY 10065.
Camila PulidoDepartment of Biochemistry, Weill Cornell Medicine, New York, NY 10065.ORCID 0000-0002-5648-066X
Ariana N TkachukHHMI, Ashburn, VA 20147.ORCID 0000-0001-8991-9643
Jocelyn Shuxin YaoHHMI, Ashburn, VA 20147.ORCID 0000-0002-8007-8160
Timothy A BrownHHMI, Ashburn, VA 20147.ORCID 0000-0001-8941-7678
Timothy A RyanHHMI, Ashburn, VA 20147.ORCID 0000-0003-2533-9548

Funding

Physiology of Single Synaptic CNS TerminalsR01NS036942 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Timothy Aidan Ryan · 1998 to 2026
$6.8M
Physiology of Single Synaptic CNS TerminalsR37NS036942 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI RYAN, TIMOTHY AIDAN · 2016 to 2022
$3.5M
Metabolic Vulnerability of Synapses in Neurodegenerative DiseaseR01NS117139 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI RYAN, TIMOTHY AIDAN · 2020 to 2024
$2.0M
Aligning Science Across Parkinson's (ASAP) ASAP-000580HHS | National Institutes of Health (NIH) NS036942HHS | National Institutes of Health (NIH) NS11739Michael J. Fox Foundation for Parkinson's Research (MJFF) ASAP-000580NINDS NIH HHS R01 NS036942NINDS NIH HHS R01 NS117139NINDS NIH HHS R37 NS036942
6 · The paper itself

Abstract

We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular compartments. iATPSnFR2 is a variant of iATPSnFR1, a previously developed sensor that has circularly permuted superfolder green fluorescent protein (GFP) inserted between the ATP-binding helices of the

Indexed as

Adenosine TriphosphateGreen Fluorescent ProteinsAnimalsBiosensing TechniquesHumansOxidative PhosphorylationProton-Translocating ATPasesAdenosine TriphosphateGreen Fluorescent ProteinsProton-Translocating ATPasesATPfluorescent sensorneuronal metabolism

Identifiers

PMID38748581
PMCPMC11126915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.