Evidence map›Paper›PMID 38748575›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain.

Timothy A Troppoli, Chun Yang, Fumi Katsuki, David S Uygun, Ilyan Lin, David D Aguilar, Tristan Spratt, Radhika Basheer, James M McNally, C Savio Chan and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Evo-devo applied to sleep research: an approach whose time has come.Sleep advances : a journal of the Sleep Research Society · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Timothy A TroppoliDepartment of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0002-2110-3274
Chun YangDepartment of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0002-1979-0335
Fumi KatsukiDepartment of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0002-1411-6317
David S UygunDepartment of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0002-6592-3223
Ilyan LinWheaton College, Norton, MA 02766.
David D AguilarDepartment of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0001-8029-9003
Tristan SprattDepartment of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0003-4055-3198
Radhika BasheerDepartment of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0002-4052-6897
James M McNallyDepartment of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0002-6043-8560
C Savio ChanDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0002-3474-1718
James T McKenna *Department of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0002-9710-3553
Ritchie E Brown *Department of Psychiatry, Veterans Affairs Boston Healthcare System, Boston, MA 02132.ORCID 0000-0002-7164-4132

Funding

Striatopallidal GABAergic Signaling in Mouse Models of Parkinson's DiseaseR01NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2010 to 2021
$3.9M
Neural Correlates of Sleep HomeostasisR01NS119227 · NINDS · HARVARD MEDICAL SCHOOL · PI BASHEER, RADHIKA · 2021 to 2025
$1.6M
Investigation of Pallidal Neurons in Motor InhibitionR01NS136123 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Savio Chan · 2024 to 2026
$1.2M
Alteration of sleep and cortical parvalbumin interneurons in mouse model of Alzheimers diseaseK01AG068366 · NIA · HARVARD MEDICAL SCHOOL · PI KATSUKI, FUMI · 2021 to 2025
$607k
Subcortical influence on the respiratory coordination of cortical neurodynamicsrelated to cognitionR21MH125242 · NIMH · HARVARD MEDICAL SCHOOL · PI MCKENNA, JAMES TIMOTHY, MCNALLY, JAMES M · 2021 to 2022
$363k
Using CRISPR-Cas9 genetic abscission in vivo to study the role of GABA-A receptors of the thalamic reticular nucleus in regulating non-rapid-eye-movement sleep and drug induced sleepIK2BX004905 · VA · VA BOSTON HEALTH CARE SYSTEM · PI UYGUN, DAVID SAMUEL · 2020 to 2024
–
Specification of sleep-wake control neurons in the basal forebrainI01BX004673 · VA · VA BOSTON HEALTH CARE SYSTEM · PI BROWN, RITCHIE EDWARD · 2020 to 2024
–
Tuning cortical E/I balance for translational modeling of psychiatric disordersI01BX004500 · VA · VA BOSTON HEALTH CARE SYSTEM · PI JAMES M MCNALLY · 2019 to 2026
–
BLRD VA I01 BX004500BLRD VA I01 BX004673BLRD VA IK2 BX004905NIA NIH HHS K01 AG068366NIMH NIH HHS R21 MH125242NINDS NIH HHS R01 NS069777NINDS NIH HHS R01 NS119227NINDS NIH HHS R01 NS136123
6 · The paper itself

Abstract

Here, we describe a group of basal forebrain (BF) neurons expressing neuronal Per-Arnt-Sim (PAS) domain 1 (Npas1), a developmental transcription factor linked to neuropsychiatric disorders. Immunohistochemical staining in Npas1-cre-2A-TdTomato mice revealed BF Npas1

Indexed as

Basal ForebrainBasic Helix-Loop-Helix ProteinsGABAergic NeuronsWakefulnessAnimalsMaleMice, TransgenicSleepBasic Helix-Loop-Helix ProteinsGABAnucleus basalisparvalbuminsleepventral pallidum

Identifiers

PMID38748575
PMCPMC11127008

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.