Evidence map›Paper›PMID 38748429›Full record

ArticleJAMA network open2024

Prioritization of Randomized Clinical Trial Questions for Children Hospitalized With Common Conditions: A Consensus Statement.

Eric R Coon, Corrie E McDaniel, Natalia Paciorkowski, Meg Grimshaw, Elizabeth Frakes, Lilliam Ambroggio, Katherine A Auger, Eyal Cohen, Matthew Garber, Peter J Gill and 12 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA network open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Eric R CoonDepartment of Pediatrics, Intermountain Primary Children's Hospital, Salt Lake City, Utah.
Corrie E McDanielDivision of Hospital Medicine, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle.
Natalia PaciorkowskiDepartment of Pediatrics, Rochester General Hospital, Rochester, New York.
Meg GrimshawDepartment of Pediatrics, Intermountain Primary Children's Hospital, Salt Lake City, Utah.
Elizabeth FrakesDepartment of Pediatrics, Intermountain Primary Children's Hospital, Salt Lake City, Utah.
Lilliam AmbroggioSection of Hospital Medicine, Children's Hospital Colorado, University of Colorado, Aurora.
Katherine A AugerDivision of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Eyal CohenThe Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Matthew GarberPediatric Hospital Medicine, University of Florida COM-Jacksonville, Jacksonville.
Peter J GillThe Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Rebecca JenningsDepartment of Pediatrics, St Charles Hospital, Bend, Oregon.
Neha Shirish JoshiDivision of Pediatric Hospital Medicine, Stanford University School of Medicine, Stanford, California.
JoAnna K LeyenaarDartmouth Health, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire.
Russell McCullohDivision of Pediatric Hospital Medicine, University of Nebraska Medical Center, Omaha.
Matthew S PantellDivision of Pediatric Hospital Medicine, University of California, San Francisco.
Hadley S Sauers-FordDivision of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Alan R SchroederDivision of Pediatric Hospital Medicine, Stanford University School of Medicine, Stanford, California.
Raj SrivastavaDepartment of Pediatrics, Intermountain Primary Children's Hospital, Salt Lake City, Utah.
Marie E WangDivision of Pediatric Hospital Medicine, Stanford University School of Medicine, Stanford, California.
Karen M WilsonDepartment of Pediatrics, Golisano Children's Hospital, Rochester, New York.
Sunitha V KaiserDivision of Pediatric Hospital Medicine, University of California, San Francisco.
RCT conference series group

Funding

AHRQ HHS R13 HS028761
6 · The paper itself

Abstract

Importance: There is a lack of randomized clinical trial (RCT) data to guide many routine decisions in the care of children hospitalized for common conditions. A first step in addressing the shortage of RCTs for this population is to identify the most pressing RCT questions for children hospitalized with common conditions. Objective: To identify the most important and feasible RCT questions for children hospitalized with common conditions. Design, Setting, and Participants: For this consensus statement, a 3-stage modified Delphi process was used in a virtual conference series spanning January 1 to September 29, 2022. Forty-six individuals from 30 different institutions participated in the process. Stage 1 involved construction of RCT questions for the 10 most common pediatric conditions leading to hospitalization. Participants used condition-specific guidelines and reviews from a structured literature search to inform their development of RCT questions. During stage 2, RCT questions were refined and scored according to importance. Stage 3 incorporated public comment and feasibility with the prioritization of RCT questions. Main Outcomes and Measures: The main outcome was RCT questions framed in a PICO (population, intervention, control, and outcome) format and ranked according to importance and feasibility; score choices ranged from 1 to 9, with higher scores indicating greater importance and feasibility. Results: Forty-six individuals (38 who shared demographic data; 24 women [63%]) from 30 different institutions participated in our modified Delphi process. Participants included children's hospital (n = 14) and community hospital (n = 13) pediatricians, parents of hospitalized children (n = 4), other clinicians (n = 2), biostatisticians (n = 2), and other researchers (n = 11). The process yielded 62 unique RCT questions, most of which are pragmatic, comparing interventions in widespread use for which definitive effectiveness data are lacking. Overall scores for importance and feasibility of the RCT questions ranged from 1 to 9, with a median of 5 (IQR, 4-7). Six of the top 10 selected questions focused on determining optimal antibiotic regimens for 3 common infections (pneumonia, urinary tract infection, and cellulitis). Conclusions and Relevance: This consensus statementhas identified the most important and feasible RCT questions for children hospitalized with common conditions. This list of RCT questions can guide investigators and funders in conducting impactful trials to improve care and outcomes for hospitalized children.

Indexed as

ConsensusDelphi TechniqueRandomized Controlled Trials as TopicChildChild, HospitalizedChild, PreschoolFemaleHospitalizationHumansInfantMale

Identifiers

PMID38748429
PMCPMC12857807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.