Evidence map›Paper›PMID 38748356›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2024

Identification and Molecular Docking Analysis of Angiotensin-Converting Enzyme Inhibitors from Finger Millet (Eleusine coracana).

Byungkwon Han, Se Yeong Park, Eunwoo Jeong, Youjin Baek, Jin Young Lee, Hyun-Joo Kim, Hyeon Gyu Lee

Abstract read
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In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Byungkwon HanDepartment of Food and Nutrition, Hanyang University, Wangsimni-ro 222, Seongdong-gu, Seoul, 04763, Republic of Korea.
Se Yeong ParkDepartment of Food and Nutrition, Hanyang University, Wangsimni-ro 222, Seongdong-gu, Seoul, 04763, Republic of Korea.
Eunwoo JeongDepartment of Food and Nutrition, Hanyang University, Wangsimni-ro 222, Seongdong-gu, Seoul, 04763, Republic of Korea.
Youjin BaekDepartment of Food and Nutrition, Hanyang University, Wangsimni-ro 222, Seongdong-gu, Seoul, 04763, Republic of Korea.
Jin Young LeeDepartment of Central Area Crop Science, National Institute of Crop Science, Rural Development Administration, Suwon, 16613, Republic of Korea.
Hyun-Joo KimDepartment of Central Area Crop Science, National Institute of Crop Science, Rural Development Administration, Suwon, 16613, Republic of Korea.
Hyeon Gyu LeeDepartment of Food and Nutrition, Hanyang University, Wangsimni-ro 222, Seongdong-gu, Seoul, 04763, Republic of Korea. hyeonlee@hanyang.ac.kr.ORCID http://orcid.org/0000-0002-9141-9469

Funding

Rural Development Administration PJ014150032021
6 · The paper itself

Abstract

Hypertension remains a significant global health concern, contributing significantly to cardiovascular diseases and mortality rates. The inhibition of angiotensin-converting enzyme (ACE) plays a crucial role in alleviating high blood pressure. We investigated the potential of finger millets (Eleusine coracana) as a natural remedy for hypertension by isolating and characterizing its ACE-inhibitory compound. First, we evaluated the ACE-inhibitory activity of the finger millet ethanol extract and subsequently proceeded with solvent fractionation. Among the solvent fractions, the ethyl acetate fraction exhibited the highest ACE inhibitory activity and was further fractionated. Using preparative high-performance liquid chromatography, the ethyl acetate fraction was separated into four subfractions, with fraction 2 (F2) exhibiting the highest ACE inhibitory activity. Subsequent 1 H-nuclear magnetic resonance (NMR) and 13 C-NMR analyses confirmed that the isolated compound from F2 was catechin. Furthermore, molecular docking studies indicated that catechin has the potential to act as an ACE inhibitor. These findings suggest that finger millets, particularly as a source of catechin, have the potential to be used as a natural antihypertensive.

Indexed as

Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsEleusineMolecular Docking SimulationPlant ExtractsChromatography, High Pressure LiquidHypertensionMagnetic Resonance SpectroscopyPeptidyl-Dipeptidase AAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsPeptidyl-Dipeptidase APlant ExtractsAngiotensin-converting enzymeCatechinFinger milletHypertensionMolecular dockingNuclear magnetic resonance

Identifiers

PMID38748356

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.