Evidence map›Paper›PMID 38748352›Full record

SynthesisJournal of gastrointestinal cancer2024

Survival Outcomes in Stage IV Gastric Cancer Patients with Krukenberg Tumors: A Systematic Review and Meta Analysis.

Junaid Anwar, Ahmed Abdelhakeem, Muhammad Shariq Khan, Hafiz Muhammad Arslan, Juwairiya Shuroog, Zouina Sarfraz, Ali Saeed, Anwaar Saeed

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of gastrointestinal cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junaid AnwarDepartment of Medicine, Baptist Hospitals of Southeast Texas, Beaumont, TX, 77701, USA.
Ahmed AbdelhakeemDepartment of Medicine, Baptist Hospitals of Southeast Texas, Beaumont, TX, 77701, USA.
Muhammad Shariq KhanDepartment of Medicine, Baptist Hospitals of Southeast Texas, Beaumont, TX, 77701, USA.
Hafiz Muhammad ArslanDepartment of Medicine, Lincoln Medical and Mental Health Center, Bronx, NY, 10451, USA.
Juwairiya ShuroogDepartment of Medicine, TidalHealth Peninsula Regional, Salisbury, MD, 21801, USA.
Zouina SarfrazDepartment of Medicine, Fatima Jinnah Medical University, Lahore, Pakistan.
Ali SaeedDepartment of Medicine, Ochsner Lafayette General Medical Center, Lafayette, LA, 70503, USA.
Anwaar SaeedDepartment of Medicine, Division of Hematology & Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15232, USA. saeeda3@upmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStage IV gastric cancer patients with Krukenberg tumors typically exhibit poor survival outcomes, often less than 2 years. The management of this tumor subgroup remains non-standardized, and the impact of oophorectomy on survival remains uncertain. In this study, we systematically analyzed survival outcomes among gastric cancer patients with ovarian metastases who underwent standard chemotherapy, surgical resection of ovarian metastases, or combined chemotherapy and surgery.

methodsWe conducted a systematic review and meta-analysis of randomized controlled trials and observational studies retrieved from MEDLINE (PubMed), Embase, and the Cochrane Library until January 25, 2024, applying the Boolean logic. Participants included individuals with pathologically and radiologically confirmed ovarian metastasis or clinically symptomatic cases with imaging evidence. Statistical analyses were performed using R (v.4.3.2., Vienna). The study was registered with PROSPERO (ID-CRD42023488373).

resultsA total of 1502 patients from 17 retrospective studies were pooled for analysis of overall survival (OS) outcomes. The OS in the standard chemotherapy cohort, as determined by the random effects model, was 6.708 months (95% CI 3.867 to 9.548; P<0.0001), with non-significant heterogeneity (I

conclusionThis meta-analysis offers key insights into survival outcomes associated with different therapeutic modalities in gastric cancer with Krukenberg metastases. It provides valuable evidence for clinical decision-making and future research directions. While the combined approach of chemotherapy and surgery demonstrates the highest effect size for OS, careful consideration of patient-centric approaches is essential in the oncological care landscape.

Indexed as

Krukenberg TumorNeoplasm StagingOvarian NeoplasmsStomach NeoplasmsFemaleHumansOvariectomySurvival RateChemotherapyGastric cancerMetastasectomyOvarian metastasisOverall survivalSurgery

Identifiers

PMID38748352

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.