Evidence map›Paper›PMID 38747849›Full record

ArticleRevista do Instituto de Medicina Tropical de Sao Paulo2024

SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient.

Maria Cassia Mendes-Correa, Fábio de Rose Ghilardi, Matias Chiarastelli Salomão, Lucy Santos Villas-Boas, Anderson Vicente de Paula, Heuder Gustavo Oliveira Paiao, Antonio Charlys da Costa, Tânia Regina Tozetto-Mendoza, Wilton Freire, Flavia Cristina Silva Sales and 4 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista do Instituto de Medicina Tropical de Sao Paulo, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria Cassia Mendes-CorreaUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5655-8108
Fábio de Rose GhilardiUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-9875-2339
Matias Chiarastelli SalomãoHospital 9 de Julho, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5507-0063
Lucy Santos Villas-BoasUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.
Anderson Vicente de PaulaUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.
Heuder Gustavo Oliveira PaiaoUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-4358-1146
Antonio Charlys da CostaUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5516-5177
Tânia Regina Tozetto-MendozaUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-5659-1052
Wilton FreireUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.
Flavia Cristina Silva SalesUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-9048-0030
Ingra Morales ClaroUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-8637-2910
Ester Cerdeira SabinoUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-2623-5126
Nuno Rodrigues FariaUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-8839-2798
Steven Sol WitkinUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-3502-3929

Funding

Medical Research Council MR/X020258/1
6 · The paper itself

Abstract

This study aimed to provide further insight into the evolutionary dynamics of SARS-CoV-2 by analyzing the case of a 40-year-old man who had previously undergone autologous hematopoietic stem cell transplantation due to a diffuse large B-cell lymphoma. He developed a persistent SARS-CoV-2 infection lasting at least 218 days and did not manifest a humoral immune response to the virus during this follow-up period. Whole-genome sequencing and viral cultures confirmed a persistent infection with a replication-positive virus that had undergone genetic variation for at least 196 days after symptom onset.

Indexed as

COVID-19Immunocompromised HostSARS-CoV-2Virus SheddingAdultHematopoietic Stem Cell TransplantationHumansLymphoma, Large B-Cell, DiffuseMaleWhole Genome Sequencing

Identifiers

PMID38747849
PMCPMC11095242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.