Evidence map›Paper›PMID 38747696›Full record

ReviewAnnals of the American Thoracic Society2024

The Management of Mild Pulmonary Hypertension in Clinical Practice.

Katarina Zeder, Evan Brittain, Gabor Kovacs, Bradley A Maron

Abstract readReview
In one paragraph

Review in Annals of the American Thoracic Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Advancing the diagnosis of pulmonary arterial hypertension-a Brazilian perspective aligned with global standards.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2026
    Article
  2. Article
  3. Article
  4. Beyond the Lung: Viewing Treatment Response through the Liver in Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katarina ZederDepartment of Pulmonology, Medical University of Graz and Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.ORCID 0000-0002-8415-727X
Evan BrittainDivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0001-5843-3392
Gabor KovacsDepartment of Pulmonology, Medical University of Graz and Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.ORCID 0000-0003-3709-2183
Bradley A MaronDivision of Cardiovascular Medicine, University of Maryland School of Medicine, Baltimore, Maryland; and.ORCID 0000-0002-6784-764X

Funding

Targeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertensionR01HL139613 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Sirano Dhe-Paganon, Bradley Maron · 2018 to 2026
$4.1M
Clinical and Mechanistic Understanding of Right Ventricular Steatosis in Pulmonary Arterial HypertensionR01HL155278 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Evan L Brittain · 2022 to 2026
$3.8M
Clinical, Genetic, and Proteomic Risk Factors for Pulmonary Hypertension in Heart FailureR01HL146588 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRITTAIN, EVAN L, FREIBERG, MATTHEW S · 2019 to 2022
$3.4M
Network Medicine and Systems Pharmacology to Advance Precision Medicine in Combined Pulmonary HypertensionR01HL163960 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Evan L Brittain, Anna R Hemnes · 2022 to 2026
$3.4M
NEDD9-SMAD3, fibrinolysis, and chronic thromboembolic pulmonary hypertensionR01HL153502 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2020 to 2023
$1.7M
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertensionR01HL155096 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2021 to 2024
$1.6M
Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible IndividualsR01FD007627 · FDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AUSTIN, ERIC DOUGLAS, BRITTAIN, EVAN L · 2022 to 2025
$1.6M
The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) StudyR61HL158941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRITTAIN, EVAN L · 2022 to 2022
$773k
FDA HHS R01 FD007627NHLBI NIH HHS R01 HL139613NHLBI NIH HHS R01 HL146588NHLBI NIH HHS R01 HL153502NHLBI NIH HHS R01 HL155096NHLBI NIH HHS R01 HL155278NHLBI NIH HHS R01 HL163960NHLBI NIH HHS R61 HL158941NIH HHS R01FD007627NIH HHS R01HL139613-01NIH HHS R01HL146588NIH HHS R01HL153502NIH HHS R01HL155096NIH HHS R01HL155278NIH HHS R01HL163960NIH HHS R61HL158941
6 · The paper itself

Abstract

The definition of pulmonary hypertension (PH) has been revised recently, with the mean pulmonary artery pressure (mPAP) threshold (assessed by right heart catheterization) reduced from ⩾25 mm Hg to >20 mm Hg. This change reflects the mPAP upper limit of normal and a lower limit that is independently associated with adverse outcomes. To improve the specificity of diagnosing pathogenic increases in mPAP, however, a diagnosis of precapillary PH now also includes pulmonary vascular resistance >2.0 Wood units (WU) (lowered from >3.0 WU). These changes are positioned to capture approximately 55% more patients with PH. Because all clinical trials showing a benefit of pulmonary vasodilator therapy in precapillary PH used the classical hemodynamic definition, the approach to the diagnosis and management of patients with mild PH (i.e., mPAP 21-24 mm Hg and pulmonary vascular resistance 2-3 WU) requires particular consideration. Here, we use a question/answer format to discuss key areas in the management of mild PH, including practical information tailored to clinicians without training in PH.

Indexed as

Cardiac CatheterizationHypertension, PulmonaryVascular ResistanceVasodilator AgentsDisease ManagementHumansPulmonary ArteryVasodilator Agentsdefinitionmanagementpulmonary hypertensiontreatment

Identifiers

PMID38747696
PMCPMC11298986

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.