Trial reportAmerican journal of respiratory and critical care medicine2024
Pulmonary Hypertension and Anastrozole (PHANTOM): A Randomized, Double-Blind, Placebo-Controlled Trial.
Abstract readRandomized Controlled TrialClinical Trial, Phase IIMulticenter Study
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- International Liver Transplantation Society practice guideline update on portopulmonary hypertension.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026Guideline
- Management of pulmonary arterial hypertension in systemic sclerosis: from classical treatments to new horizons.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Trial
- Rodatristat ethyl decreases activity in pulmonary arterial hypertension: results from the ELEVATE-2 trial.Annals of the American Thoracic Society · 2026Trial
- Effect of Famotidine on Outcomes in Pulmonary Arterial Hypertension: A Randomized Controlled Trial.Chest · 2025Trial
- When Good Biology Meets Negative Clinical Trials: Lessons from PHANTOM and EDIPHY.Annals of the American Thoracic Society · 2026Article
- Metabolomics of Right Ventricular Function in Pulmonary Hypertension.Circulation research · 2026Article
- Update on pulmonary hypertension.Respiratory research · 2026Review
- Cardiomyocyte NLRP3 signaling in right heart failure is sexually dimorphic via estrogen receptor α.bioRxiv : the preprint server for biology · 2026Article
- Sex Differences in Pulmonary Hypertension and Associated Right Ventricular Dysfunction.The American journal of cardiology · 2026Article
- Longitudinal Remote 6-Minute Walk Distance and Cardiac Effort Using Wearable Sensors in Pulmonary Hypertension.Pulmonary circulation · 2026Article
- Pathophysiology of Pulmonary Arterial Hypertension: Focus on Vascular Endothelium as a Potential Therapeutic Target.International journal of molecular sciences · 2025Review
- Sex differences in pulmonary (arterial) hypertension: does it matter?Current opinion in pulmonary medicine · 2025Review
- Liver bypass in the development of pathogen-associated pulmonary vascular disease: contribution of mesocaval and portosystemic shunts.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Sex-dependent Pathophysiology and Therapeutic Considerations in Right Heart Disease.The Canadian journal of cardiology · 2025Review
- Channeling Hope in the Expanding Landscape of Therapy for Pulmonary Hypertension: Potential Role for Piezo2.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Review
- Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes.Cellular & molecular biology letters · 2024Review
- Searching for an Elusive Phantom - Targeting Estrogen in Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2024Article
- Pathology and pathobiology of pulmonary hypertension: current insights and future directions.The European respiratory journal · 2024Review
Corrections and comments
- Commented on by
Authors and funding
20 authors.
Steven M KawutDepartment of Medicine.ORCID 0000-0001-7896-0608
Rui FengDepartment of Biostatistics, Epidemiology, and Informatics, and.
Susan S EllenbergDepartment of Biostatistics, Epidemiology, and Informatics, and.
Roham ZamanianDepartment of Medicine, Stanford University, Stanford, California.
Todd BullPulmonary Vascular Disease Center, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Denver, Colorado.
Murali ChakinalaDepartment of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Stephen C MathaiDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0003-3188-7209
Anna HemnesDepartment of Medicine and.ORCID 0000-0002-2755-5845
Grace LinDepartment of Medicine, Mayo Clinic, Rochester, Minnesota.
Margaret DoyleDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Ruth AndrewUniversity/British Heart Foundation, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Margaret MacLeanStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom; and.
Ioannis StasinopoulosUniversity/British Heart Foundation, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Eric AustinDepartment of Pediatrics, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0002-1709-9022
Angela DeMicheleDepartment of Medicine.
Haochang ShouDepartment of Biostatistics, Epidemiology, and Informatics, and.
Jasleen MinhasDepartment of Medicine.ORCID 0000-0001-7864-6096
Nianfu SongDepartment of Biostatistics, Epidemiology, and Informatics, and.
Jude MoutchiaDepartment of Biostatistics, Epidemiology, and Informatics, and.
Corey E VentetuoloDepartment of Medicine and.ORCID 0000-0002-4223-4775
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MAnastrozole in Pulmonary Arterial Hypertension (AIPH2) - CCC (Lead)R01HL134905 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2017 to 2021
$5.5MEffects of DHEA in Pulmonary Hypertension (DiPH)R01HL141268 · NHLBI · RHODE ISLAND HOSPITAL · PI VENTETUOLO, COREY E · 2018 to 2022
$3.7MAnastrozole in Pulmonary Arterial Hypertension (AIPH2) - DCCR01HL134904 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ELLENBERG, SUSAN S · 2017 to 2021
$990kBritish Heart Foundation RG/F/21/110047Medical Research Council MR/T015713NCATS NIH HHS UL1 TR002243NHLBI NIH HHS 5UL1TR002243-03NHLBI NIH HHS R01 HL134904NHLBI NIH HHS R01 HL134905NHLBI NIH HHS R01 HL141268
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnastrozoleAromatase InhibitorsAgedDouble-Blind MethodFemaleHumansHypertension, PulmonaryMaleMiddle AgedNitrilesPostmenopauseTreatment OutcomeWalk TestAnastrozoleAromatase InhibitorsNitrilesanastrozoleclinical trialpulmonary hypertensionsex hormones
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.