Trial reportThe Journal of clinical endocrinology and metabolism2025
Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Adolescent Brain Morphology.
Trial report in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Brain Microstructure.The Journal of clinical endocrinology and metabolism · 2025Trial
- No significant impact of levothyroxine treatment of maternal subclinical hypothyroidism on brain morphology in adolescence: insight from long-term follow up of Controlled Antenatal Thyroid Screening (CATS) study.Annals of translational medicine · 2026Article
- Update on the Risk Factors for Thyroid Dysfunction in Pregnancy.Biomedicines · 2026Review
- Comment on "association between maternal thyroid dysfunction and neurodevelopmental disorders in offspring: a population-based cohort study".European child & adolescent psychiatry · 2026Article
- Thyroid diseases and risk of peripheral neuropathy in a large population-based cohort: evidence from the UK Biobank.Frontiers in endocrinology · 2026Article
- Neighborhood deprivation and iodine levels influence air pollution effects on maternal thyroid function in early pregnancy.Environmental research · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
contextChildren born to mothers with gestational hypothyroidism or hyperthyroidism may have increased risk of adverse neurodevelopmental outcomes. However, the effects of maternal thyroid status on offspring brain development are unclear.
objectiveThis work aimed to establish whether adolescent brain morphology is affected by suboptimal gestational thyroid function (SGTF).
methodsThe Controlled Antenatal Thyroid Screening (CATS) study randomly assigned mothers with SGTF to levothyroxine or no supplementation from approximately 12 weeks' gestation. At age 9, children born to mothers who were overtreated with levothyroxine had a higher risk of conduct and hyperactivity traits. For the current CATS III study, children underwent neuroimaging studies, including T1-weighted structural magnetic resonance imaging (MRI). A total of 85 children aged 11 to 16 years had usable T1-weighted MRI data (exposed to untreated SGTF [n = 21], normal GTF [n = 24], or treated SGTF [optimally treated (n = 21), overtreated (n = 20)]). The primary outcome was to examine the association of SGTF and its treatment with global brain volumes. Secondary and exploratory outcomes were to investigate the association of maternal thyrotropin (TSH) and free thyroxine (FT4) levels with global and subregional brain volumes. Results were adjusted for age, sex, and pubertal scores.
resultsThere were no significant differences in global brain volumetric measures between groups, including total gray matter volume (P = .373). Weak positive correlations were found between maternal TSH, but not FT4, levels and several brain volumes, but these did not survive testing for multiple comparisons.
conclusionWe found no evidence that SGTF was associated with differences in adolescent brain morphology, and no effect of levothyroxine supplementation.
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