Evidence map›Paper›PMID 38747161›Full record

ArticleExperimental physiology2024

Using modified Fenn diagrams to assess ventilatory acclimatization during ascent to high altitude: Effect of acetazolamide.

Rodion Isakovich, Valerie C Cates, Brandon A Pentz, Jordan D Bird, Emily R Vanden Berg, Emily M de Freitas, Cassandra E Nysten, Jack K Leacy, Ken D O'Halloran, Thomas D Brutsaert and 2 more

Abstract read
In one paragraph

Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rodion IsakovichDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.
Valerie C CatesDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.
Brandon A PentzDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.
Jordan D BirdDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.
Emily R Vanden BergDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.
Emily M de FreitasDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.
Cassandra E NystenDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.
Jack K LeacyDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.
Ken D O'HalloranDepartment of Physiology, School of Medicine, College of Medicine & Health, University Cork College, Cork, Ireland.ORCID 0000-0002-8832-1153
Thomas D BrutsaertDepartment of Exercise Science, Syracuse University, Syracuse, New York, USA.
Mingma T SherpaKunde Hospital, Khunde, Solukhumbu, Nepal.
Trevor A DayDepartment of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.ORCID 0000-0001-7102-4235

Funding

Department of Physiology, University College Cork, IrelandNatural Sciences and Engineering Research Council of Canada Discovery grant RGPIN-2016-04915
6 · The paper itself

Abstract

High altitude (HA) ascent imposes systemic hypoxia and associated risk of acute mountain sickness. Acute hypoxia elicits a hypoxic ventilatory response (HVR), which is augmented with chronic HA exposure (i.e., ventilatory acclimatization; VA). However, laboratory-based HVR tests lack portability and feasibility in field studies. As an alternative, we aimed to characterize area under the curve (AUC) calculations on Fenn diagrams, modified by plotting portable measurements of end-tidal carbon dioxide (

Indexed as

AcclimatizationAcetazolamideAltitudeCarbonic Anhydrase InhibitorsOximetryPulmonary VentilationAdministration, OralAdolescentAdultAltitude SicknessArea Under CurveFemaleHumansMaleMountaineeringNepalAcetazolamideCarbonic Anhydrase Inhibitorsacclimatizationacetazolamideacute mountain sicknesshigh altitude ascenthypoxic ventilatory response

Identifiers

PMID38747161
PMCPMC11215491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.