ArticleJournal of pediatric gastroenterology and nutrition2024
High prevalence of gastrointestinal disorders in a large cohort of patients with joint hypermobility.
Article in Journal of pediatric gastroenterology and nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Gastrointestinal Manifestations of Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: A Mentored Review.Digestive diseases and sciences · 2026Review
- Children and adolescents with disorders of gut-brain interaction with comorbid hypermobility and orthostatic intolerance have worse outcomes.Journal of pediatric gastroenterology and nutrition · 2026Article
- Age-related symptom clustering in pediatric hypermobility spectrum disorders: a scoping review.Orphanet journal of rare diseases · 2026Article
- Article
- Postsurgical Disorders of the Gut-Brain Axis and the Need for Multidisciplinary Treatment Approach: Authors' Reply.Neurogastroenterology and motility · 2026Article
- A Roadmap for Advancing Women's Health in Disorders of the Gut-Brain Interaction.United European gastroenterology journal · 2026Review
- Overlap of Structural Gastrointestinal Disorders in Children With Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Review
- Comprehensive Motility Analysis in Patients with Hypermobility Spectrum Disorders and Gastrointestinal Symptoms: An Exploratory Tertiary Care Study.Digestive diseases and sciences · 2025Article
- The prevalence and predictive factors of overlapping disorders of gut-brain interaction and celiac disease in children.Journal of pediatric gastroenterology and nutrition · 2025Article
- Observational
- Suspected Mitochondrial Dysfunction and Complex Pathophysiology in Fatal Hypermobile Ehlers-Danlos Syndrome: Insights from a Case Report and Post-Mortem Findings.Biomedicines · 2025Article
- Liquid and solid gastric emptying and correlation with clinical characteristics in pediatric patients with dyspepsia.Neurogastroenterology and motility · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The gastrointestinal (GI) manifestations in children with hypermobile Ehlers-Danlos syndrome/joint hypermobility syndrome (hEDS/JHS) are not well described. We investigated the prevalence of GI disorders in children and young adults with hEDS/JHS through a single-center retrospective review. Demographic data, clinical history, symptoms, and diagnostic studies were reviewed. Of 435 patients with hEDS/JHS, 66% were females (age 5-28 years). We noted a high prevalence of constipation (61%), dysphagia (32%), dyspepsia and/or gastroparesis (25%), eosinophilic esophagitis (EoE) (21%), and celiac disease (4%) in our cohort. Upper endoscopy and gastric emptying scans had the highest yield to detect abnormalities. Motility studies were abnormal in 31% of the 80 patients who underwent them. Dysphagia symptoms are significantly associated with EoE. Thirty-three percent of dysphagia patients had EoE, versus 16% of non-dysphagia patients (p < 0.001). Screening hEDS/JHS patients for GI issues should be routine, with further investigations and referrals guided by identified symptoms.
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