ArticleJournal of Taibah University Medical Sciences2024
Evaluation of the mechanical properties and degradation behavior of chitosan-PVA-graphene oxide nanocomposite scaffolds in vitro.
Article in Journal of Taibah University Medical Sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Objectives: Chitosan (CTS) has been a popular option for scaffold fabrication because of its biocompatibility, biodegradability, antimicrobial and nonimmunogenic effects. However, it is of limited function, due to its low mechanical strength and its solubility in acidified media. These limitations could be overcome by its blending with PVA and incorporation with bioactive materials to improve its mechanical properties and tissue regeneration capability. Methods: Carbon based nanomaterials, such as graphene oxide (GO) incorporated with CTS/PVA blend to improve composite-scaffold stability. GO nanoparticles were chemically prepared and fully characterized. Different concentrations of both CTS and nano-GO were used for the fabrication of CTS/PVA/GO nanocomposite films through the solvent-casting method. The mechanical properties, thermal stability biodegradation, and swelling of the nanocomposite films were evaluated after characterization by XRD, FTIR and SEM, to detect the effect of GO incorporation in the scaffold to select the suitable dental application. Results: A better performance was observed in thermal stability, biodegradation, and water resistance after GO addition into CTS/PVA scaffolds. Regarding mechanical properties, groups were assessed by Conclusions: CTS/PVA/GO nanocomposite can be used in dental hard tissue engineering, as the incorporation of GO into the CTS/PVA polymer blend improves its properties which is regarded as the critical concentrations of CTS and GO.
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