Evidence map›Paper›PMID 38746895›Full record

ArticleACS medicinal chemistry letters2024

Structural Evaluations of a Selective Human STING

Zhichao Tang, Junxing Zhao, Ying Li, Shallu Tomer, Manikandan Selvaraju, Nicholas Tien, Diyun Sun, David K Johnson, Anjie Zhen, Pingwei Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhichao TangDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States.
Junxing ZhaoDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States.
Ying LiDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
Shallu TomerDivision of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, United States.
Manikandan SelvarajuDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States.
Nicholas TienDivision of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, United States.
Diyun SunDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.ORCID https://orcid.org/0009-0008-4939-2304
David K JohnsonComputation Chemical Biology Core and Molecular Graphics and Modeling Laboratory, University of Kansas, Lawrence, Kansas 66047, United States.ORCID https://orcid.org/0000-0003-4262-8173
Anjie ZhenDivision of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, United States.
Pingwei LiDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.
Jingxin WangDepartment of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States.

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
UCLA-CDU CFARP30AI152501 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Homero Erwin del Pino · 2022 to 2026
$15.6M
Induction of autophagy to enhance CAR-T cells in HIV cure approachesR01AI172727 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARSDEN, MATTHEW DAVID, ZHEN, ANJIE · 2022 to 2025
$3.9M
Molecular basis of viral DNA sensing through the cGAS-STING pathwayR01AI145287 · NIAID · TEXAS A&M AGRILIFE RESEARCH · PI Pingwei Li · 2019 to 2026
$2.5M
Modulating gene expression by RNA-targeting chimerasR35GM147498 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Jingxin Wang · 2022 to 2026
$2.1M
Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infectionR01DA052841 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G, ZHEN, ANJIE · 2020 to 2024
$1.9M
A Universal CAR-NK Cell Targeting Various Epitopes of HIV-1R21AI155117 · NIAID · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI XIE, JIANMING, ZHEN, ANJIE · 2020 to 2021
$460k
NIAID NIH HHS P30 AI152501NIAID NIH HHS R01 AI145287NIAID NIH HHS R01 AI172727NIAID NIH HHS R21 AI155117NIDA NIH HHS R01 DA052841NIGMS NIH HHS P20 GM103638NIGMS NIH HHS R35 GM147498
6 · The paper itself

Abstract

Previously we identified a non-nucleotide agonist BDW568 that selectively activates the human STING

Identifiers

PMID38746895
PMCPMC11089548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.