Evidence map›Paper›PMID 38746443›Full record

ArticlebioRxiv : the preprint server for biology2024

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model.

Xin Li, Chaozhong Liu, Wenbo Li, Yanwan Dai, Chaohao Gu, Wenjun Zhou, Veronica C Ciliberto, Jing Liang, Kumar S Udhaya, Dongyin Guan and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Xin LiDepartment of Medicine - Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA.
Chaozhong LiuDepartment of Pediatrics, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
Wenbo LiDepartment of Medicine - Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA.
Yanwan DaiDepartment of Pediatrics, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
Chaohao GuDepartment of Pediatrics, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
Wenjun ZhouDepartment of Medicine - Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA.
Veronica C CilibertoDepartment of Medicine - Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA.
Jing LiangDepartment of Medicine - Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA.
Kumar S UdhayaDepartment of Medicine - Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA.
Dongyin GuanDepartment of Medicine - Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA.
Zhaoyong HuDepartment of Medicine - Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA.
Hui ZhengHuffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA.
Hu ChenDepartment of Pediatrics, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
Zhandong LiuDepartment of Pediatrics, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0002-7608-0831
Ying-Wooi WanDepartment of Pediatrics, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
Zheng SunDepartment of Medicine - Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas 77030, USA.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Tissue ResourceP50CA126752 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, HELEN E HESLOP · 2007 to 2026
$51.4M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7M
Epigenomic Remodeling of Metabolism by Exercise through AP-1R01DK111436 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2020
$2.0M
Circadian clock gene Rev-erb in memory dysfunction in Alzheimer's diseaseRF1AG069966 · NIA · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2021 to 2021
$1.8M
Circadian clock gene Rev-erb in memory dysfunction in Alzheimer's diseaseR01AG069966 · NIA · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2024 to 2025
$1.1M
Enduring effects of high estrogen on Alzheimer's diseaseR03AG070687 · NIA · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2021 to 2021
$320k
Acquisition of 10X Genomics Chromium Instrument to Accelerate Genomic and Single Cell Transcriptomic ResearchS10OD025240 · OD · BAYLOR COLLEGE OF MEDICINE · PI DODDAPANENI, HARSHA VARDHAN · 2018 to 2018
$125k
NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA126752NIA NIH HHS R01 AG069966NIA NIH HHS R03 AG070687NIA NIH HHS RF1 AG069966NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK111436NIEHS NIH HHS P30 ES030285NIH HHS S10 OD025240
6 · The paper itself

Abstract

Physical exercise represents a primary defense against age-related cognitive decline and neurodegenerative disorders like Alzheimer's disease (AD). To impartially investigate the underlying mechanisms, we conducted single-nucleus transcriptomic and chromatin accessibility analyses (snRNA-seq and ATAC-seq) on the hippocampus of mice carrying AD-linked NL-G-F mutations in the amyloid precursor protein gene (APP

Indexed as

Alzheimer’s diseasecognitiongrowth factorhippocampusPhysical exercise

Identifiers

PMID38746443
PMCPMC11092636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.