Evidence map›Paper›PMID 38746434›Full record

ArticlebioRxiv : the preprint server for biology2025

Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci.

Mohammad M Rahman, Svetlana Zamakhaeva, Jeffrey S Rush, Catherine T Chaton, Cameron W Kenner, Yin Mon Hla, Ho-Ching Tiffany Tsui, Vladimir N Uversky, Malcolm E Winkler, Konstantin V Korotkov and 1 more

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In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mohammad M RahmanDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0003-2881-5132
Svetlana ZamakhaevaDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0001-9971-4211
Jeffrey S RushDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.
Catherine T ChatonDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-2843-3559
Cameron W KennerDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA.
Yin Mon HlaDepartment of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.ORCID 0009-0009-1076-4622
Ho-Ching Tiffany TsuiDepartment of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.ORCID 0000-0003-0849-874X
Vladimir N UverskyDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-4037-5857
Malcolm E WinklerDepartment of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.ORCID 0000-0002-1482-2588
Konstantin V KorotkovDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-2182-6843
Natalia KorotkovaDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-8696-4892

Funding

New Regulatory Interactions and Circuits that Mediate the Dynamics, Homeostasis, and Stress Responses of Peptidoglycan Synthesis in the Superbug Streptococcus pneumoniaeR35GM131767 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI MALCOLM E. WINKLER · 2019 to 2026
$4.8M
Biosynthesis, structure and function of cell wall in Streptococcus mutansR01DE028916 · NIDCR · UNIVERSITY OF KENTUCKY · PI KOROTKOVA, NATALIA · 2020 to 2024
$1.8M
Identification of the factors contributing to resistance of Group A Streptococcus to human group IIA secreted phospholipase A2R21AI149366 · NIAID · UNIVERSITY OF KENTUCKY · PI KOROTKOVA, NATALIA · 2020 to 2021
$415k
Mechanisms of resistance against the human group IIA secreted phospholipase A2 in Group B StreptococcusR21AI146945 · NIAID · UNIVERSITY OF KENTUCKY · PI KOROTKOVA, NATALIA · 2020 to 2021
$412k
NIAID NIH HHS R21 AI146945NIAID NIH HHS R21 AI149366NIDCR NIH HHS R01 DE028916NIGMS NIH HHS R35 GM131767
6 · The paper itself

Abstract

Proteins harboring intrinsically disordered regions (IDRs) lacking stable secondary or tertiary structures are abundant across the three domains of life. These regions have not been systematically studied in prokaryotes. Our genome-wide analysis identifies extracytoplasmic serine/threonine-rich IDRs in several biologically important membrane-associated proteins in streptococci. We demonstrate that these IDRs are glycosylated with glucose by glycosyltransferases GtrB and PgtC2 in

Indexed as

biofilmfoldaseintrinsically disordered regionO-glycosylationsecreted peptidyl-prolyl isomeraseStreptococcus mutansStreptococcus pneumoniaeStreptococcus pyogenes

Identifiers

PMID38746434
PMCPMC11092751

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.