Evidence map›Paper›PMID 38746316›Full record

ArticlebioRxiv : the preprint server for biology2024

Perinatal maternal undernutrition in baboons modulates hepatic mitochondrial function but not metabolites in aging offspring.

Daniel A Adekunbi, Bowen Yang, Hillary F Huber, Angelica M Riojas, Alexander J Moody, Cun Li, Michael Olivier, Peter W Nathanielsz, Geoffery D Clarke, Laura A Cox and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel A AdekunbiDepartment of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, Texas, USA.ORCID 0000-0001-5456-3392
Bowen YangResearch Imaging Institute, Long School of Medicine, The University of Texas Health Science Center at San Antonio, Ant Texas, USA.
Hillary F HuberSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.ORCID 0000-0001-9734-427X
Angelica M RiojasResearch Imaging Institute, Long School of Medicine, The University of Texas Health Science Center at San Antonio, Ant Texas, USA.ORCID 0000-0002-4918-407X
Alexander J MoodyResearch Imaging Institute, Long School of Medicine, The University of Texas Health Science Center at San Antonio, Ant Texas, USA.ORCID 0000-0003-1834-2175
Cun LiTexas Pregnancy and Life-course Health Research Center, Department of Animal Science, University of Wyoming, Laramie, Wyoming, USA.
Michael OlivierCenter for Precision Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-1632-1063
Peter W NathanielszTexas Pregnancy and Life-course Health Research Center, Department of Animal Science, University of Wyoming, Laramie, Wyoming, USA.ORCID 0000-0001-8410-6280
Geoffery D ClarkeResearch Imaging Institute, Long School of Medicine, The University of Texas Health Science Center at San Antonio, Ant Texas, USA.ORCID 0000-0003-4559-6437
Laura A CoxCenter for Precision Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-8836-3783
Adam B SalmonDepartment of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, Texas, USA.ORCID 0000-0002-1475-7843

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Womb to Tomb: Developmental Programming and Aging Interactions in PrimatesU19AG057758 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CLARKE, GEOFFREY DAVID, COX, LAURA A · 2018 to 2024
$13.2M
TRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4M
Primary fibroblast resiliency as a predictor of health and lifespan in miceR01AG057431 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SALMON, ADAM · 2017 to 2021
$1.6M
NIA NIH HHS P30 AG013319NIA NIH HHS R01 AG057431NIA NIH HHS T32 AG021890NIA NIH HHS U19 AG057758NIH HHS P51 OD011133
6 · The paper itself

Abstract

We previously demonstrated in baboons that maternal undernutrition (MUN), achieved by 70 % of control nutrition, impairs fetal liver function, but long-term changes associated with aging in this model remain unexplored. Here, we assessed clinical phenotypes of liver function, mitochondrial bioenergetics, and protein abundance in adult male and female baboons exposed to MUN during pregnancy and lactation and their control counterparts. Plasma liver enzymes were assessed enzymatically. Liver glycogen, choline, and lipid concentrations were quantified by magnetic resonance spectroscopy. Mitochondrial respiration in primary hepatocytes under standard culture conditions and in response to metabolic (1 mM glucose) and oxidative (100 µM H

Indexed as

baboonsbioenergeticsdevelopmental programminghepatocytesliver

Identifiers

PMID38746316
PMCPMC11092655

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.