Evidence map›Paper›PMID 38746312›Full record

ArticleResearch square2024

Regulation of Vascular Endothelial Integrity by Mesenchymal Stem Cell Extracellular Vesicles after Hemorrhagic Shock and Trauma.

Mark Barry, Alpa Trivedi, Byron Miyazawa, Lindsay Vivona, David Shimmin, Praneeti Pathipati, Callie Keane, Joseph Cuschieri, Shibani Pati

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Mark BarryUniversity of California San Francisco.ORCID 0000-0003-2353-3312
Alpa TrivediUniversity of California San Francisco.
Byron MiyazawaUniversity of California San Francisco.
Lindsay VivonaUniversity of California San Francisco.
David ShimminUniversity of California San Francisco.
Praneeti PathipatiUniversity of California San Francisco.
Callie KeaneUniversity of California San Francisco.
Joseph CuschieriUniversity of California San Francisco.
Shibani PatiUniversity of California San Francisco.

Funding

Modulation of Pulmonary Vascular Permeability and Inflammation by Mesenchymal Stem Cells (MSCs) in Hemorrhagic ShockR01GM111899 · NIGMS · VITALANT · PI PATI, SHIBANI · 2015 to 2019
$1.6M
NIGMS NIH HHS R01 GM111899
6 · The paper itself

Abstract

backgroundPatients with hemorrhagic shock and trauma (HS/T) are vulnerable to the endotheliopathy of trauma (EOT), characterized by vascular barrier dysfunction, inflammation, and coagulopathy. Cellular therapies such as mesenchymal stem cells (MSCs) and MSC extracellular vesicles (EVs) have been proposed as potential therapies targeting the EOT. In this study we investigated the effects of MSCs and MSC EVs on endothelial and epithelial barrier integrity

methods

resultsMSC EVs and MSC CM attenuated permeability and preserved intercellular junctions of the PEC monolayer

conclusionsIn conclusion, MSC EVs could be a potential cell-free therapy targeting endotheliopathy after HS/T via preservation of the vascular endothelial barrier in multiple organs early after injury. Further research is needed to better understand the immunomodulatory effects of these products following HS/T and to move toward translating these therapies into clinical studies.

Indexed as

hemorrhagic shockmesenchymal stem cell extracellular vesiclesmesenchymal stem cellstrauma

Identifiers

PMID38746312
PMCPMC11092837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.